BIM 189 acts as bombesin antagonist that reduces bombesin-induced satiety.
CAT No: R0869
CAS No:142062-55-3
Synonyms/Alias:[D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2
BIM 189 is a synthetic peptide compound recognized for its selective and potent antagonistic activity at the melanocortin 4 receptor (MC4R), a G protein-coupled receptor implicated in the regulation of energy homeostasis, feeding behavior, and neuroendocrine signaling. As a research-grade peptide, BIM 189 serves as a valuable molecular tool for elucidating the physiological and biochemical pathways governed by MC4R, enabling precise interrogation of receptor function in both in vitro and in vivo experimental systems. Its well-characterized structure and high receptor specificity make it a preferred choice for studies aiming to dissect melanocortin signaling mechanisms and their broader implications in metabolic and neurological research fields.
Receptor Pharmacology: In receptor pharmacology research, BIM 189 is widely utilized to investigate the functional roles of MC4R in cellular and animal models. By acting as a selective antagonist, it allows researchers to specifically block MC4R-mediated signaling, thereby facilitating the differentiation of receptor-specific effects from those mediated by related melanocortin receptors. This targeted approach is critical for mapping receptor-ligand interactions, characterizing downstream signaling cascades, and validating MC4R as a molecular target in diverse physiological contexts.
Metabolic Regulation Studies: The compound is instrumental in metabolic research focused on appetite control, energy expenditure, and body weight regulation. By inhibiting MC4R activity, BIM 189 enables the study of melanocortin pathway disruptions that contribute to metabolic phenotypes. Researchers employ it to model the effects of MC4R dysfunction, providing insights into the molecular underpinnings of obesity, hyperphagia, and related metabolic disorders in preclinical settings. Such studies support the identification of novel targets for metabolic modulation and further the understanding of energy balance regulation.
Neuroendocrine Signaling Research: BIM 189 is frequently used to probe the role of MC4R in neuroendocrine pathways, particularly those involving stress response, sexual function, and hypothalamic-pituitary-adrenal axis regulation. By selectively antagonizing MC4R, the peptide enables precise delineation of receptor-specific contributions to neuroendocrine outputs. This application is crucial for unraveling the complex interplay between central melanocortin circuits and endocrine function, advancing knowledge in neurobiology and endocrine physiology.
Peptide Structure-Activity Relationship (SAR) Analysis: The compound serves as a reference molecule in peptide SAR studies aimed at optimizing MC4R ligand design. Researchers utilize BIM 189 to benchmark the activity, selectivity, and binding affinity of novel peptide analogs or small-molecule modulators targeting the melanocortin system. Its well-documented pharmacological profile provides a reliable standard for comparative analysis, supporting rational drug design and the development of next-generation receptor modulators.
In vitro Assay Development: BIM 189 is also employed in the development and validation of in vitro assay systems for screening MC4R ligands. Its consistent antagonistic activity makes it suitable as a positive control or reference antagonist in cell-based functional assays, radioligand binding studies, and high-throughput screening platforms. The use of this peptide in assay development enhances the reliability and reproducibility of experimental results, facilitating the discovery and characterization of novel compounds that interact with the melanocortin pathway.
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