BIM 23056 behaves as a potent and selective antagonist of somatostatin receptor 5.
CAT No: R0827
CAS No:150155-61-6
Synonyms/Alias:150155-61-6;BIM 23056;D-Alaninamide, D-phenylalanyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-3-(2-naphthalenyl)-;(2S)-6-Amino-N-[(2S)-1-[[(2S)-1-[[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide;FFYWKVFA;D-Phe-Phe-Tyr-D-Trp-Lys-Val-Phe-D-Nal-NH2;CHEMBL410596;SCHEMBL12912367;BDBM82256;BIM23056;AKOS024456811;DA-61666;DC-25-20;PD079144;CAS_150155-61-6;G12888;(2S)-6-AMINO-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2R)-2-AMINO-3-PHENYLPROPANAMIDO]-3-PHENYLPROPANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]-3-(1H-INDOL-3-YL)PROPANAMIDO]-N-[(1S)-1-{[(1S)-1-{[(1R)-1-CARBAMOYL-2-(NAPHTHALEN-2-YL)ETHYL]CARBAMOYL}-2-PHENYLETHYL]CARBAMOYL}-2-METHYLPROPYL]HEXANAMIDE;D-Alaninamide,D-phenylalanyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-3-(2-naphthalenyl)-;
BIM 23056 is a synthetic peptide compound known for its function as a selective somatostatin receptor subtype 2 (SSTR2) agonist. Structurally derived from somatostatin analogues, it exhibits high affinity and specificity for SSTR2, making it a valuable tool in neuroendocrine research and receptor pharmacology. Its ability to modulate somatostatin-mediated signaling pathways has established its relevance in studies investigating hormone secretion, neurotransmitter regulation, and cell signaling mechanisms. The compound's stability and receptor selectivity enable precise experimental manipulation of somatostatin pathways, supporting a broad range of biochemical and physiological investigations.
Receptor Pharmacology: As a potent and selective agonist for SSTR2, BIM 23056 is extensively employed in receptor binding assays and functional studies aimed at characterizing somatostatin receptor pharmacodynamics. Researchers utilize the compound to delineate SSTR2-specific signaling cascades, allowing for the assessment of ligand-receptor interactions, second messenger responses, and downstream effector modulation. Such studies are fundamental to understanding the differential roles of somatostatin receptor subtypes in various tissues and experimental models.
Signal Transduction Research: In cellular and molecular biology, BIM 23056 serves as a critical tool for dissecting somatostatin-induced signal transduction pathways. By selectively activating SSTR2, investigators can probe the roles of G-protein coupled receptor signaling, cyclic AMP inhibition, and calcium flux modulation. This enables detailed exploration of intracellular events following receptor engagement, facilitating the mapping of signaling networks that regulate secretion, proliferation, and differentiation in neuroendocrine and other cell types.
Endocrine Secretion Studies: The compound is widely used to study the regulation of hormone secretion, particularly in pancreatic, pituitary, and gastrointestinal systems. Through selective SSTR2 activation, BIM 23056 allows researchers to investigate the inhibitory effects of somatostatin analogues on the release of insulin, growth hormone, and other peptide hormones. This application provides valuable insights into feedback mechanisms and receptor subtype contributions to endocrine homeostasis, supporting the development of new hypotheses in hormone regulation research.
Neuroscience Applications: Within neuroscience, BIM 23056 is instrumental in elucidating the role of somatostatinergic signaling in neural circuits. Its selective action on SSTR2 enables the study of neurotransmitter release modulation, synaptic plasticity, and neuronal excitability. Researchers leverage the compound to explore the physiological and pathophysiological implications of somatostatin signaling in the central and peripheral nervous systems, deepening understanding of neuropeptide function in brain and nerve tissue.
Peptide Drug Development: The structural and functional properties of BIM 23056 make it a reference compound in the development and evaluation of novel somatostatin analogues. Medicinal chemists and pharmacologists use it as a benchmark for assessing receptor affinity, selectivity, and biological activity in drug discovery programs targeting somatostatin receptors. This application supports the rational design of new peptide-based ligands with tailored pharmacological profiles for research and industrial purposes.
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