BIO-11006 acetate salt, an analog of the MANS peptide, is a myristoylated alanine-rich C kinase substrate (MARCKS) inhibitor.
CAT No: R1238
BIO-11006 acetate salt is a synthetic peptide compound that functions as a specific inhibitor of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein. As a cell-permeable peptide, it is designed to disrupt the interaction between MARCKS and the plasma membrane, thereby modulating downstream signaling pathways associated with cytoskeletal regulation, cell motility, and cellular signaling events. The acetate salt form enhances its solubility and stability for use in biochemical and cell-based research applications. Owing to its precise mechanism of action, BIO-11006 has become a valuable tool for researchers investigating the roles of MARCKS in diverse physiological and pathological contexts, particularly in cellular signaling, neurobiology, and cancer biology.
Signal transduction studies: BIO-11006 acetate salt is widely employed in studies aiming to dissect the function of MARCKS in cellular signal transduction. By inhibiting MARCKS, researchers can elucidate its involvement in pathways regulated by protein kinase C (PKC), which is critical for processes such as cell proliferation, differentiation, and migration. The compound's specificity allows for precise modulation of MARCKS-dependent signaling events, facilitating mechanistic investigations into how this substrate influences downstream effectors and cellular outcomes.
Cytoskeletal dynamics research: The peptide is instrumental in examining the regulation of actin cytoskeleton organization. MARCKS is known to bind actin filaments and phospholipids, playing a pivotal role in cytoskeletal rearrangements. Using BIO-11006, scientists can disrupt MARCKS-actin interactions, thereby probing the molecular mechanisms underlying cell shape changes, membrane ruffling, and motility. Such studies are particularly relevant in the context of neurobiology, wound healing, and metastasis research, where cytoskeletal remodeling is a key event.
Cell migration and invasion assays: The ability of BIO-11006 to modulate MARCKS activity makes it a preferred tool in assays designed to assess cell migration and invasion. By interfering with MARCKS-mediated signaling, the peptide enables detailed analysis of the molecular determinants governing cellular movement. This is of particular interest in cancer research, where understanding the regulation of metastatic potential can inform the development of targeted intervention strategies and provide insights into tumor progression.
Neuroscience investigations: The compound finds significant application in neurobiological research, where MARCKS is implicated in neuronal development, synaptic plasticity, and neurotransmitter release. Employing BIO-11006 in in vitro and ex vivo models allows researchers to delineate the contributions of MARCKS to neuronal signaling and plasticity. These studies shed light on fundamental processes such as neurite outgrowth, synaptic remodeling, and the molecular basis of learning and memory.
Peptide-based inhibitor validation: Beyond its specific biological targets, BIO-11006 acetate salt serves as a model system for validating peptide-based inhibitors of protein-protein and protein-membrane interactions. Its well-characterized mode of action and cell-permeable properties provide a foundation for comparative studies, optimization of peptide design, and the development of next-generation research tools targeting similar molecular interactions. This utility extends to structure-activity relationship (SAR) analyses and the evaluation of delivery strategies for peptide therapeutics in preclinical research settings.
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