Biophen CS 01(81) presents a peptide-like scaffold designed for in vitro biochemical measurements, particularly protease or coagulation studies. Residue configuration influences substrate accessibility and charge distribution. Researchers use it to examine cleavage kinetics and interaction specificity. Applications include enzymatic profiling, method validation, and biophysical analysis.
CAT No: PI-021
CAS No:86890-95-1
Synonyms/Alias:86890-95-1;N-P-Tosyl-Gly-Pro-Arg P-nitroanilide acetate salt;N-(p-Tosyl)-GPR-pNA acetate;N-(p-Tosyl)-GPR-pNA (acetate);acetic acid;(2S)-N-[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]-1-[2-[(4-methylphenyl)sulfonylamino]acetyl]pyrrolidine-2-carboxamide;Thrombin Substrate I;Biophen CS 01(81);SCHEMBL3507728;NGXDRWVTRQRSED-VROPFNGYSA-N;AKOS024436556;AKOS032957197;AKOS040755540;FT172225;TS-08858;HY-138143;CS-0145492;NS00066176;N-p-tosyl-gly-pro-argp-nitroanilideacetatesalt;N-(p-tosyl)-gly-pro-arg-p-nitroanilide acetate salt;N-(p-Tosyl)-Gly-Pro-Arg p-nitroanilide acetate salt, thrombin substrate;(S)-N-((S)-5-guanidino-1-(4-nitrophenylamino)-1-oxopentan-2-yl)-1-(2-(4-methylphenylsulfonamido)acetyl)pyrrolidine-2-carboxamide acetate;
Biophen CS 01(81) is a specialized biochemical reagent designed for in vitro research applications, particularly within the field of hemostasis and coagulation studies. As a chromogenic substrate-based assay system, its core utility lies in the quantitative measurement of protein C activity in plasma, enabling precise functional assessment of this critical anticoagulant pathway. The reagent's optimized formulation ensures reliable enzymatic reactions, making it a valuable tool for laboratories investigating the complex interplay of coagulation factors and their regulation. Its robust performance and specificity have established it as a trusted choice for researchers seeking accurate analysis of protein C function in various experimental contexts.
Coagulation Research: In the study of blood coagulation mechanisms, Biophen CS 01(81) provides a sensitive and reproducible method for assessing protein C activity. Protein C plays an essential role in the regulation of thrombin generation and the prevention of excessive clot formation. By enabling direct quantification of functional protein C levels, the reagent supports investigations into the molecular basis of coagulation disorders, anticoagulant pathways, and the physiological balance between procoagulant and anticoagulant forces. Its application is particularly relevant in elucidating the pathogenesis of thrombophilia and other hemostatic abnormalities.
Diagnostic Assay Development: The chromogenic substrate assay offered by this reagent is widely implemented in the development and validation of laboratory tests for protein C deficiency. Its high specificity for activated protein C ensures minimal interference from other plasma proteins, facilitating the establishment of reliable diagnostic protocols. Scientists and technical teams utilize it as a benchmark tool for assay calibration, method comparison, and the refinement of analytical techniques in clinical research laboratories, contributing to enhanced diagnostic accuracy for coagulation-related conditions.
Quality Control in Plasma-Derived Product Manufacturing: Biophen CS 01(81) is frequently employed in the quality control assessment of plasma-derived therapeutics, such as protein C concentrates. Manufacturers rely on its precise quantification capabilities to monitor the functional integrity of protein C during production and final product release. By providing consistent and reproducible measurements, the reagent supports compliance with stringent quality assurance requirements and helps ensure the safety and efficacy of plasma-derived products for research purposes.
Pharmacological and Biochemical Studies: In pharmacological research, the reagent serves as a critical tool for evaluating the impact of novel compounds, anticoagulants, or genetic modifications on the protein C pathway. Researchers utilize it to investigate the modulation of protein C activity under varying experimental conditions, enabling a deeper understanding of drug mechanisms, resistance phenomena, and the interplay between therapeutic agents and endogenous anticoagulant systems. The ability to monitor functional protein C levels in vitro supports the rational design and optimization of new anticoagulant strategies for laboratory investigation.
Comparative Analysis of Animal and Human Samples: The versatility of Biophen CS 01(81) extends to comparative studies involving plasma samples from different species. Its robust assay design allows for the cross-species evaluation of protein C activity, facilitating translational research and the validation of animal models in hemostasis studies. By enabling standardized measurement across diverse biological matrices, the reagent aids in bridging preclinical findings with human biology, supporting the advancement of coagulation research and the development of innovative experimental approaches.
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