Neurogranin is a post synaptic protein that is expressed in dendritic cytoplasm. It modulates calcium-mediated signaling pathways and plays critical role in synaptic plasticity. Recently Neurogranin (48-76) was identified as a major neurogranin peptide fragment in human brain and it was found that patients with Alzheimer’s Disease have elevated levels of Neurogranin (48-76) in cerebrospinal fluid.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
M.W/Mr. | 2644.1 |
Sequence | One Letter Code: Biotin-SGERGRKGPGPGGPGGAGVARGGAGGGPS Three Letter Code: biotin-Ser-Gly-Glu-Arg-Gly-Arg-Lys-Gly-Pro-Gly-Pro-Gly-Gly-Pro-Gly-Gly-Ala-Gly-Val-Ala-Arg-Gly-Gly-Ala-Gly-Gly-Gly-Pro-Ser-OH |
References | 1. De Vos A., et.al., Alzh and Dement 4, 1-9 (2015) |
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