Bulevirtide is a potent antiviral peptide used in the biomedical industry. It exhibits strong inhibitory activity against hepatitis delta virus (HDV), a severe co-infection with hepatitis B virus (HBV) that causes chronic liver disease.
CAT No: R2015
CAS No:2012558-47-1
Synonyms/Alias:Bulevirtide;Bulevirtide (INN);Bulevirtide [INN];2012558-47-1;bulevirtidum;Bulevirtida;Hepcludextm;Hepcludex;Hepcludex (TN);formerly Myrcludex B;MYRCLUDEX;Bulevirtide [USAN];WKM56H3TLB;BULEVIRTIDE [WHO-DD];915207G;N-TETRADECANOYLGLYCYL-THR-ASN-LEU-SER-VAL-PRO-ASN-PRO-LEU-GLY-PHE-PHE-PRO-ASP-HIS-GLN-LEU-ASP-PRO-ALA-PHE-GLY-ALA-ASN-SER-ASN-ASN-PRO-ASP-TRP-ASP-PHE-ASN-PRO-ASN-LYS-ASP-HIS-TRP-PRO-GLU-ALA-ASN-LYS-VAL-GLY-NH2;
Bulevirtide is a synthetic lipopeptide compound designed to mimic and competitively inhibit specific viral entry mechanisms at the cellular membrane. As a highly specialized peptide, it is structurally engineered to interact with the sodium taurocholate co-transporting polypeptide (NTCP), a key receptor involved in the uptake of bile acids and the entry of certain viral pathogens into hepatocytes. Its unique molecular configuration and receptor specificity have made it a valuable tool in the investigation of viral-host interactions, particularly those relevant to liver-targeting viruses. The compound's capacity to selectively block NTCP-mediated processes has established its significance in both fundamental and applied biochemical research focused on membrane transport, viral pathogenesis, and peptide-receptor binding dynamics.
Viral Entry Inhibition Studies: Bulevirtide is extensively utilized in research focused on elucidating the molecular mechanisms by which viruses, especially hepatitis B and D viruses, gain entry into hepatocytes. By serving as a potent NTCP antagonist, it enables scientists to dissect the critical steps of viral attachment and penetration at the cellular level. Experimental systems employing this peptide facilitate the identification of host-pathogen interactions, allowing for the mapping of viral entry pathways and the validation of NTCP as a principal viral receptor in hepatic tissue.
Membrane Transport Investigations: The compound's affinity for NTCP also makes it an effective probe for studying bile acid transport and the broader physiological roles of this transporter in hepatic function. Researchers employ bulevirtide to selectively inhibit NTCP-mediated uptake of bile salts, thereby modeling the consequences of transporter blockade in vitro. These studies yield insights into bile acid metabolism, transporter specificity, and the regulation of hepatic uptake processes, supporting advances in both basic liver biology and transporter-targeted drug discovery.
Peptide-Receptor Binding Analysis: As a synthetic lipopeptide with high receptor specificity, bulevirtide serves as a model ligand in receptor-ligand binding studies. Its application in biochemical assays and structural analyses provides critical data on the binding kinetics, affinity, and conformational changes associated with peptide-receptor interactions. Such investigations are instrumental for the rational design of novel peptides or small molecules targeting NTCP or similar membrane proteins, furthering the development of selective molecular probes.
Antiviral Screening Assays: Bulevirtide is incorporated into in vitro screening platforms to evaluate the efficacy of new antiviral agents targeting NTCP-dependent viral entry. By establishing a functional blockade of the receptor, it acts as a reference inhibitor, enabling comparative assessment of candidate compounds. This approach supports the identification and optimization of molecules with potential to disrupt viral infection at the entry stage, thereby contributing to the pipeline of antiviral research and development.
Cellular Model Development: In the context of advanced cell culture systems, bulevirtide is used to generate NTCP-deficient models or to transiently inhibit NTCP function in hepatocyte-derived cell lines. These tailored cellular models are critical for studying the physiological and pathological roles of NTCP, as well as for dissecting the impact of transporter inhibition on cellular homeostasis, signaling pathways, and susceptibility to viral infection. The use of this peptide thus underpins the creation of robust experimental platforms for liver biology and infectious disease research.
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