Carbetocin Impurity 1 is a synthetic byproduct differing subtly from carbetocin in residue arrangement or oxidation state. These modifications influence disulfide geometry and chromatographic behaviors. Researchers use it to refine impurity-profiling methods. Applications include QC development, stability assessment, and synthetic-route optimization.
CAT No: Z10-101-178
CAS No:1352167-71-5
Synonyms/Alias:((3R,6S,9S,12S,15S)-6-(2-Amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-((S)-sec-butyl)-15-(4-methoxybenzyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosane-3-carbonyl)-L-prolyl-L-leucylglycine;2-((S)-2-((S)-1-((3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-((S)-sec-butyl)-15-(4-methoxybenzyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosane-3-carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)acetic acid;
Carbetocin impurity 1 is a synthetic peptide derivative structurally related to carbetocin, a well-characterized oxytocin analog. As a defined impurity standard, it represents a specific byproduct or degradation product encountered during the synthesis or storage of carbetocin. The presence and identification of such impurities are of critical importance in peptide research, pharmaceutical development, and quality control workflows. Carbetocin impurity 1 serves as a valuable analytical reference, enabling researchers to investigate the chemical stability, synthetic fidelity, and overall integrity of carbetocin preparations in both academic and industrial settings.
Analytical method development: Carbetocin impurity 1 is widely employed as a reference standard for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). By providing a well-characterized impurity profile, it allows researchers and quality control specialists to establish robust protocols for the detection, quantification, and resolution of structurally related byproducts in peptide samples. The availability of this impurity standard enhances the accuracy and reproducibility of impurity profiling, supporting regulatory compliance and process optimization in peptide manufacturing.
Stability studies: The compound plays a crucial role in forced degradation and stability-indicating studies of carbetocin formulations. By introducing carbetocin impurity 1 into test samples, scientists can simulate real-world degradation pathways and evaluate the resilience of the parent peptide under various stress conditions, such as heat, pH fluctuations, or oxidative environments. These investigations help elucidate degradation mechanisms, inform formulation strategies, and guide the design of storage protocols to ensure product quality over time.
Process optimization in peptide synthesis: In the context of synthetic process development, carbetocin impurity 1 acts as a marker for monitoring the efficiency and selectivity of peptide coupling reactions. Its detection in reaction mixtures can signal incomplete or side reactions, prompting optimization of synthetic parameters such as reagent choice, reaction time, and purification techniques. By tracking the formation and clearance of this impurity, chemists can refine manufacturing processes to minimize byproduct formation and maximize yield and purity of the target peptide.
Reference material for impurity identification: The defined structure and properties of carbetocin impurity 1 make it an indispensable tool for confirming the identity of unknown peaks in chromatographic or spectrometric analyses. When analyzing carbetocin batches or related peptide products, the impurity standard can be spiked into samples to verify retention times, fragmentation patterns, and spectral signatures. This approach facilitates unambiguous identification of impurities, supporting both routine quality control and investigative research into peptide degradation or contamination events.
Peptide formulation research: The presence of well-characterized impurities such as carbetocin impurity 1 enables formulation scientists to assess the impact of trace byproducts on the stability, solubility, and compatibility of peptide-based products. By incorporating known impurities into formulation studies, researchers can evaluate potential interactions with excipients, container materials, or other formulation components. These insights contribute to the development of robust, high-quality peptide formulations suitable for research and industrial applications, while also informing risk assessments and product specifications.
1. High fat diet and GLP-1 drugs induce pancreatic injury in mice
3. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
4. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
5. TMEM16F and dynamins control expansive plasma membrane reservoirs
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More