Caspase-2 Inhibitor Z-VDVAD-FMK

Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies.

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CAT#R1111
CAS210344-95-9
Synonyms/AliasBenzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
M.F/FormulaC32H46FN5O11
M.W/Mr.695.7
SequenceVDVAD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Asp-2 = Asp(OMe); Asp-5 = Asp(OMe))
Labeling TargetCaspase-2
ApplicationZ-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity.
AppearanceWhite lyophilised solid
Purity>98%
ActivityInhibitor
Areas of InterestCell Biology
Cancer
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