CEF8, Influenza Virus NP (383-391), an influenza A virus nucleoprotein containing residues 383 to 391, is the most important HLA-B*2705-restricted epitope in the nucleoprotein of influenza A viruses and is associated with escape from cytotoxic T lymphocytes-mediated immunity.
CAT No: R1283
CAS No:142479-13-8
Synonyms/Alias:MK-2206 (dihydrochloride);142479-13-8;CEF8, Influenza Virus NP (383-391);NH2-Ser-Arg-Tyr-Trp-Ala-Ile-Arg-Thr-Arg-COOH;MK-2206 (2HCl);HY-P1835;AKOS040764030;DA-76166;HY-10358;TS-10397;CS-0096537;(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-5-carbamimidamidopentanamido]-3-(4-hydroxyphenyl)propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-methylpentanamido]-5-carbamimidamidopentanamido]-3-hydroxybutanamido]-5-carbamimidamidopentanoic acid;
CEF8, Influenza Virus NP 383-391 is a synthetic peptide derived from the nucleoprotein (NP) sequence of the influenza virus, specifically comprising residues 383 to 391. This peptide represents a well-characterized epitope recognized by cytotoxic T lymphocytes, making it highly relevant in immunological studies focused on viral antigen recognition and T cell-mediated immune responses. Due to its defined sequence and immunogenic properties, CEF8 is widely utilized as a model antigen in experimental settings investigating host-pathogen interactions, immune monitoring, and the specificity of cellular immune mechanisms.
Immunological assay development: CEF8 serves as a critical tool in the development and validation of immunological assays that assess T cell responses to viral antigens. Its defined epitope enables researchers to calibrate and optimize assays such as ELISpot, intracellular cytokine staining, and flow cytometry-based detection of antigen-specific CD8+ T cells. By providing a consistent and reproducible antigenic stimulus, the peptide allows for the precise measurement of T cell functionality and frequency in both basic research and vaccine evaluation contexts.
Epitope mapping and T cell specificity studies: The peptide is extensively employed in studies aiming to map T cell epitopes and characterize the specificity of cytotoxic T lymphocyte populations. Its use facilitates the identification of TCR repertoires responsive to influenza virus infection, aiding in the understanding of immune recognition at the molecular level. Researchers leverage this peptide to dissect the determinants of immunodominance and to investigate cross-reactivity among related viral strains, thereby advancing knowledge of adaptive immunity.
Vaccine research and immunogenicity assessment: CEF8 is instrumental in preclinical vaccine research, where it is used to evaluate the immunogenicity of candidate vaccine formulations. By serving as a benchmark epitope, the peptide enables comparative studies of T cell responses elicited by different vaccine platforms or adjuvant systems. Its application in ex vivo stimulation assays provides valuable data on the magnitude and quality of cellular immune responses, informing the rational design of next-generation influenza vaccines.
Quality control in immunomonitoring: The peptide is commonly incorporated as a positive control in immunomonitoring protocols, ensuring the reliability and sensitivity of T cell detection assays. Its robust and well-characterized reactivity with human leukocyte antigen (HLA) molecules, particularly HLA-A*0201, makes it an ideal standard for validating assay performance in clinical and research laboratories. The use of such controls is essential for minimizing false negatives and for benchmarking assay sensitivity across different experimental runs and sample cohorts.
Peptide-based mechanistic studies: CEF8 enables mechanistic investigations into antigen processing, presentation, and T cell activation pathways. Researchers utilize the peptide to probe the dynamics of peptide-MHC complex formation, stability, and recognition by T cell receptors. These studies contribute to a deeper understanding of the molecular interactions governing cellular immunity and inform the development of strategies to modulate immune responses for research and therapeutic purposes. By providing a defined system for dissecting peptide-specific immune functions, CEF8 supports advanced research in immunology and virology.
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