cGMP Dependent Kinase Inhibitor Peptide contains residues designed to disrupt substrate docking within cGMP-dependent protein kinase pathways. The sequence includes motifs influencing charge distribution, helix formation, and kinase interaction. Researchers apply it to study regulatory loops and catalytic specificity. Its defined structure supports enzymatic and mechanistic analyses.
CAT No: R0846
CAS No:82801-73-8
Synonyms/Alias:82801-73-8;Arg-Lys-Arg-Ala-Arg-Lys-Glu;PKG inhibitor peptide;cGMP Dependent Kinase Inhibitor Peptide;Arg-7-glu;RKRARKE;Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid;(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]pentanedioic acid;L-Glutamic acid, N-(N2-(N2-(N-(N2-(N2-L-arginyl-L-lysyl)-L-arginyl)-L-alanyl)-L-arginyl)-L-lysyl)-;Alg-Lys-Arg-Ala-Arg-Lys-Glu;SCHEMBL7447958;HDA80173;HY-P1292;AKOS024456827;[Ala32]-Histone H2B (29-35);DA-77486;MS-31758;CS-0029296;G12289;(S)-2-((6S,9S,12S,15S,18S,21S)-1,6-Diamino-9,21-bis(4-aminobutyl)-12,18-bis(3-guanidinopropyl)-1-imino-15-methyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosanamido)pentanedioic acid;
cGMP Dependent Kinase Inhibitor Peptide is a specialized peptide compound designed to selectively inhibit the activity of cyclic guanosine monophosphate (cGMP)-dependent protein kinases, particularly PKG isoforms. As a synthetic peptide tool, it plays a pivotal role in dissecting the molecular mechanisms governed by cGMP signaling pathways. By modulating PKG activity, this inhibitor enables researchers to elucidate the functional consequences of cGMP-mediated phosphorylation events within various cellular and physiological contexts. Its biochemical specificity and utility make it an indispensable reagent for advanced studies in signal transduction, vascular biology, neurobiology, and smooth muscle research.
Signal Transduction Research: The targeted inhibition of cGMP-dependent kinases using this peptide allows for precise interrogation of downstream signaling cascades. Researchers employ it to differentiate PKG-mediated effects from those triggered by other kinases, thereby clarifying the unique contributions of cGMP signaling in processes such as vasodilation, platelet function, and cellular proliferation. By selectively blocking PKG, the peptide facilitates the mapping of phosphorylation events and the identification of direct and indirect substrates, supporting a deeper understanding of cellular communication networks.
Vascular Biology Studies: In vascular smooth muscle research, the peptide inhibitor is widely utilized to investigate the regulatory role of PKG in modulating vascular tone and reactivity. By suppressing PKG activity, scientists can delineate the mechanisms underlying smooth muscle relaxation and contraction, providing critical insights into the control of blood pressure and vascular homeostasis. This approach is particularly valuable in studies aiming to untangle the interplay between nitric oxide, cGMP signaling, and vascular function.
Neurobiology Applications: The cGMP pathway is implicated in numerous neural processes, including synaptic plasticity, memory formation, and neuroprotection. The inhibitor peptide serves as a key tool for probing the involvement of PKG in neuronal signaling and plasticity. By blocking PKG activity in neuronal cultures or tissue preparations, researchers can assess its impact on neurotransmitter release, ion channel modulation, and gene expression, thereby advancing the understanding of cGMP-dependent mechanisms in the central and peripheral nervous systems.
Pharmacological Profiling: As a selective inhibitor, this peptide is frequently integrated into pharmacological assays to characterize the specificity and efficacy of novel compounds targeting the cGMP pathway. Its use in competitive binding and functional assays aids in distinguishing between PKG-dependent and independent effects, thereby refining the pharmacodynamic profiles of experimental agents. This application is essential for validating target engagement and for the development of new modulators of cGMP signaling.
Peptide Mechanism Elucidation: Beyond its role as a functional inhibitor, the peptide is also employed in mechanistic studies to explore the structure-activity relationships of PKG and related kinases. By analyzing the interaction between the inhibitor and its target, researchers can gain valuable information on kinase substrate recognition, allosteric regulation, and the development of next-generation peptide inhibitors. Such studies contribute to the rational design of more potent and selective modulators for research and potential industrial applications.
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