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cGMP Dependent Kinase Inhibitor Peptide

cGMP Dependent Kinase Inhibitor Peptide contains residues designed to disrupt substrate docking within cGMP-dependent protein kinase pathways. The sequence includes motifs influencing charge distribution, helix formation, and kinase interaction. Researchers apply it to study regulatory loops and catalytic specificity. Its defined structure supports enzymatic and mechanistic analyses.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
cGMP Dependent Kinase Inhibitor Peptide(CAS 82801-73-8)

CAT No: R0846

CAS No:82801-73-8

Synonyms/Alias:82801-73-8;Arg-Lys-Arg-Ala-Arg-Lys-Glu;PKG inhibitor peptide;cGMP Dependent Kinase Inhibitor Peptide;Arg-7-glu;RKRARKE;Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid;(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]pentanedioic acid;L-Glutamic acid, N-(N2-(N2-(N-(N2-(N2-L-arginyl-L-lysyl)-L-arginyl)-L-alanyl)-L-arginyl)-L-lysyl)-;Alg-Lys-Arg-Ala-Arg-Lys-Glu;SCHEMBL7447958;HDA80173;HY-P1292;AKOS024456827;[Ala32]-Histone H2B (29-35);DA-77486;MS-31758;CS-0029296;G12289;(S)-2-((6S,9S,12S,15S,18S,21S)-1,6-Diamino-9,21-bis(4-aminobutyl)-12,18-bis(3-guanidinopropyl)-1-imino-15-methyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosanamido)pentanedioic acid;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C38H74N18O10
M.W/Mr.
943.1
Sequence
One Letter Code:RKRARKE
Three Letter Code:H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH
Application
Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.
Purity
>98 %
Solubility
-20 °C
InChI
InChI=1S/C38H74N18O10/c1-21(29(59)52-26(13-8-20-50-38(46)47)33(63)54-24(11-3-5-17-40)34(64)56-27(35(65)66)14-15-28(57)58)51-31(61)25(12-7-19-49-37(44)45)55-32(62)23(10-2-4-16-39)53-30(60)22(41)9-6-18-48-36(42)43/h21-27H,2-20,39-41H2,1H3,(H,51,61)(H,52,59)(H,53,60)(H,54,63)(H,55,62)(H,56,64)(H,57,58)(H,65,66)(H4,42,43,48)(H4,44,45,49)(H4,46,47,50)/t21-,22-,23-,24-,25-,26-,27-/m0/s1
InChI Key
OUKSKNTVYYVIMZ-DUJSLOSMSA-N
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N
BoilingPoint
N/A
Melting Point
N/A

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