cGMP Dependent Kinase Inhibitor Peptide

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CAT No: R0846

CAS No: 82801-73-8

Synonyms/Alias: 82801-73-8;Arg-Lys-Arg-Ala-Arg-Lys-Glu;PKG inhibitor peptide;cGMP Dependent Kinase Inhibitor Peptide;Arg-7-glu;RKRARKE;Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid;(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]pentanedioic acid;L-Glutamic acid, N-(N2-(N2-(N-(N2-(N2-L-arginyl-L-lysyl)-L-arginyl)-L-alanyl)-L-arginyl)-L-lysyl)-;Alg-Lys-Arg-Ala-Arg-Lys-Glu;SCHEMBL7447958;HDA80173;HY-P1292;AKOS024456827;[Ala32]-Histone H2B (29-35);DA-77486;MS-31758;CS-0029296;G12289;(S)-2-((6S,9S,12S,15S,18S,21S)-1,6-Diamino-9,21-bis(4-aminobutyl)-12,18-bis(3-guanidinopropyl)-1-imino-15-methyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosanamido)pentanedioic acid;

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC38H74N18O10
M.W/Mr.943.1
SequenceOne Letter Code:RKRARKE
Three Letter Code:H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH
ApplicationCompetitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.
Purity>98 %
Solubility-20 °C
InChIInChI=1S/C38H74N18O10/c1-21(29(59)52-26(13-8-20-50-38(46)47)33(63)54-24(11-3-5-17-40)34(64)56-27(35(65)66)14-15-28(57)58)51-31(61)25(12-7-19-49-37(44)45)55-32(62)23(10-2-4-16-39)53-30(60)22(41)9-6-18-48-36(42)43/h21-27H,2-20,39-41H2,1H3,(H,51,61)(H,52,59)(H,53,60)(H,54,63)(H,55,62)(H,56,64)(H,57,58)(H,65,66)(H4,42,43,48)(H4,44,45,49)(H4,46,47,50)/t21-,22-,23-,24-,25-,26-,27-/m0/s1
InChI KeyOUKSKNTVYYVIMZ-DUJSLOSMSA-N
Isomeric SMILESC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N
BoilingPointN/A
Melting PointN/A

1. Crystal Structure of BamB from Pseudomonas aeruginosa and Functional Evaluation of Its Conserved Structural Features

2. A possible role of tachykinin-related peptide on an immune system activity of mealworm beetle, Tenebrio molitor L

3. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

4. Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation

5. Extended exenatide administration enhances lipid metabolism and exacerbates pancreatic injury in mice on a high fat, high carbohydrate diet

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