Cls Substrate, C2 (Abz/Dnp)

This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: X21170

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.W/Mr.
1326.6
Sequence
One Letter Code: 2Abz-SLGRKIQIK(Dnp)-NH2
Three Letter Code: 2Abz-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile-Lys(Dnp)-NH2
References
Kerr, F. et al. J. Biol. Chem. 280, 39510 (2005), S. Nagasawa, and R. Stroud PNAS 74, 2998 (1977).

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