CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling. CMD178 also is an inhibitor of STAT5 and inhibit Treg cell development.
CAT No: R1293
CMD178 is a synthetic peptide compound engineered for advanced biochemical research applications, particularly within the fields of signal transduction, cellular pathway elucidation, and receptor-ligand interaction studies. As a custom-designed sequence, CMD178 offers researchers a versatile tool for probing complex biological systems, enabling the dissection of protein-protein interactions and the modulation of specific cellular functions. Its defined structure and tailored amino acid composition make it a valuable asset for laboratories focused on peptide-based functional assays, mechanistic studies, and the exploration of novel therapeutic targets at the molecular level.
Peptide functional studies: CMD178 is frequently utilized in peptide functional studies to investigate the role of specific sequence motifs in modulating cellular processes. By introducing this synthetic peptide into in vitro systems, researchers can assess its impact on signaling cascades, protein recruitment, or enzyme activation, thereby gaining insights into the mechanisms governing cellular communication. Such studies are instrumental in mapping the contributions of discrete peptide domains to broader biological functions, supporting hypothesis-driven research in molecular and cellular biology.
Receptor binding assays: The compound serves as a critical reagent in receptor binding assays designed to characterize ligand specificity, affinity, and downstream signaling events. When used as a ligand or competitive inhibitor, CMD178 enables the quantitative assessment of receptor-peptide interactions, facilitating the identification of binding sites and the evaluation of potential modulatory effects. This application is essential for elucidating the molecular basis of receptor activation and for screening candidate molecules in early-stage drug discovery programs.
Protein-protein interaction mapping: CMD178 is employed in studies aimed at mapping protein-protein interactions, particularly where short peptide sequences mediate complex formation. By incorporating the peptide into pull-down assays, surface plasmon resonance experiments, or co-immunoprecipitation protocols, researchers can delineate interaction networks and identify critical contact residues. Such approaches are vital for understanding the architecture of signaling complexes and for validating interaction hypotheses derived from computational modeling or high-throughput screening.
Peptide synthesis optimization: The defined structure and sequence of CMD178 make it an ideal reference standard or model substrate for optimizing peptide synthesis methodologies. Laboratories engaged in solid-phase peptide synthesis (SPPS) or solution-phase assembly can use CMD178 to validate coupling efficiencies, assess resin performance, and refine purification protocols. This application supports the development of robust, reproducible workflows for the generation of high-quality synthetic peptides, which are foundational to both basic research and applied biotechnology.
Analytical method development: CMD178 is also valuable for the development and validation of analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and capillary electrophoresis. Its use as a calibration standard or system suitability test compound allows analytical chemists to benchmark instrument performance, optimize separation parameters, and ensure the accuracy of peptide quantification. This contributes to the reliability and reproducibility of experimental data across a range of peptide analysis platforms.
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