A peptide inhibitor of corticotropin-releasing factor binding protein (CRFBP) that displaces CRF from CRFBP, and suppresses body weight gain and increases motor activity in obese rats in vivo.
CAT No: R1023
CAS No:120066-38-8
Synonyms/Alias:CRF (6-33) (HUMAN, RAT);120066-38-8;MFCD00671436;Crf(6-33)(human,rat);DTXSID80745604;PUBCHEM_71308685;AKOS024456702;FC109011;PD086345;CRF (6-33) (human, rat) (H-L-Ile-L-Ser-L-Leu-L-Asp-L-Leu-L-Thr-L-Phe-L-His-L-Leu-L-Leu-L-Arg-L-Glu-L-Val-L-Leu-L-Glu-L-Met-L-Ala-L-Arg-L-Ala-L-Glu-L-Gln-L-Leu-L-Ala-L-Gln-L-Gln-L-Ala-L-His-L-Ser-OH);H-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-OH; H-ISLDLTFHLLRE VLEMARAEQLAQQAHS-OH;
CRF (6-33), also known as Corticotropin-Releasing Factor (6-33), is a synthetic peptide fragment derived from the native corticotropin-releasing factor sequence. As a truncated analog, it spans amino acid residues 6 through 33 of the parent peptide, thereby retaining a significant portion of the biologically active region while lacking the N-terminal segment. This peptide has garnered substantial attention in neuroendocrinology and peptide biochemistry due to its ability to act as a selective antagonist at CRF receptors. Its unique structural attributes make it a valuable tool for probing the physiological and molecular mechanisms underlying stress response modulation, hypothalamic-pituitary-adrenal (HPA) axis regulation, and peptide-receptor interactions in both basic and applied research contexts.
Receptor Antagonism Studies: CRF (6-33) is widely employed as a competitive antagonist of CRF receptors, particularly CRF1 and CRF2 subtypes. Through its selective binding, it enables researchers to investigate the functional roles of endogenous CRF signaling pathways in neuronal and endocrine systems. By blocking receptor activation, this peptide facilitates the dissection of downstream signaling cascades, gene expression changes, and physiological outcomes associated with CRF-mediated stress responses. It is especially valuable for delineating the contributions of specific CRF receptor subtypes in vitro and in ex vivo tissue preparations.
Neuroendocrine Research: The peptide fragment serves as a critical reagent in studies of HPA axis regulation and neuroendocrine feedback mechanisms. By antagonizing endogenous CRF activity, it allows for controlled manipulation of hormone release from the pituitary and adrenal glands in experimental models. Researchers utilize this tool to examine the modulation of adrenocorticotropic hormone (ACTH) secretion, stress hormone dynamics, and the interplay between central and peripheral neuroendocrine signals. Its use enhances understanding of adaptive and maladaptive responses to stress at the molecular and systemic levels.
Behavioral Neuroscience Applications: In the context of behavioral studies, CRF (6-33) is instrumental for elucidating the role of CRF signaling in stress-related behaviors, anxiety paradigms, and emotional regulation. By selectively inhibiting CRF receptor activity, the peptide enables precise assessment of the behavioral consequences of disrupted CRF signaling in animal models. This application supports investigations into the neurobiological substrates of anxiety, depression, and other affective disorders, providing insight into the molecular underpinnings of stress-induced behavioral changes.
Peptide-Receptor Interaction Analysis: The fragment's defined structure and receptor affinity make it a valuable standard for characterizing peptide-receptor interactions in binding assays and structure-activity relationship (SAR) studies. Researchers employ CRF (6-33) to map critical residues involved in receptor engagement, assess ligand specificity, and optimize novel peptide analogs or antagonists. Its use in competitive binding experiments supports the development of more selective and potent modulators of CRF receptor function for research applications.
Peptide Synthesis and Analytical Reference: Beyond functional studies, CRF (6-33) serves as a reference compound in peptide synthesis, purification, and analytical method development. Its well-characterized sequence and established chromatographic behavior provide benchmarks for quality control, mass spectrometry calibration, and method validation in peptide research laboratories. This role is essential for ensuring reproducibility and accuracy in the production and analysis of related peptide analogs and research-grade CRF derivatives.
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