H-Glu-Val-Cit-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-Cit-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser-OH forms an extended peptide rich in acidic, hydrophobic, and basic residues that shape its folding profile. Repeating Glu units influence charge distribution and structural dynamics. Researchers use it to examine domain transitions and binding-site accessibility. Applications include structural biology, peptide-material development, and motif-architecture studies.
CAT No: R2658
CAS No:1627911-44-7
Synonyms/Alias:H-Glu-Val-Cit-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-Cit-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser-OH;EX-A9846;CS 6253;1627911-44-7;
H-Glu-Val-Cit-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-Cit-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser-OH, a synthetic peptide sequence, represents a sophisticated tool in the expanding field of peptide research and carbohydrate chemistry. Characterized by its unique arrangement of amino acids, this compound is engineered for high stability and specificity, making it a valuable resource in diverse scientific investigations. Its sequence incorporates both canonical and non-canonical residues, such as citrulline, which introduce distinct biochemical properties and enable targeted interactions in experimental settings. The peptide's design allows for versatile conjugation possibilities, and its hydrophilic and hydrophobic segments facilitate various structural conformations, further broadening its utility in molecular studies. As an advanced research reagent, H-Glu-Val-Cit-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-Cit-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser-OH is frequently utilized in the development of innovative biochemical assays, as well as in the exploration of protein-carbohydrate interactions and peptide-based delivery systems.
Peptide-carbohydrate conjugation: In glycobiology research, this peptide serves as an effective scaffold for the synthesis of glycopeptide conjugates. By coupling carbohydrate moieties to specific lysine or serine residues within the sequence, researchers can generate defined glycopeptides for the study of glycosylation patterns and their effects on molecular recognition. Such conjugates are instrumental in elucidating the roles of carbohydrates in protein folding, stability, and cellular signaling pathways, providing insights into fundamental biological processes. Enzyme substrate design: H-Glu-Val-Cit-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-Cit-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser-OH is commonly employed as a customizable substrate for proteolytic enzymes. By incorporating specific cleavage sites, the peptide enables the detailed study of enzyme specificity, kinetics, and inhibition mechanisms. This application is particularly valuable in the investigation of protease function and regulation, supporting the identification of novel enzyme modulators and the optimization of enzymatic assays. Structural biology studies: The peptide's well-defined sequence and conformational flexibility make it suitable for use in structural biology, where it can serve as a model system for investigating peptide folding, aggregation, and intermolecular interactions. Its unique composition allows researchers to explore the influence of non-standard amino acids, such as citrulline, on secondary structure formation and stability, advancing the understanding of peptide architecture and dynamics.
Immune response modeling: In immunological research, synthetic peptides like this one are utilized to mimic antigenic determinants and study immune recognition mechanisms. By presenting specific epitopes, the peptide can facilitate the mapping of antibody binding sites and the characterization of T-cell responses in vitro. These studies contribute to the development of novel immunoassays and the identification of peptide motifs involved in immune modulation, supporting research in vaccine design and immunodiagnostics. Drug delivery platform development: The amphipathic nature and modular sequence of H-Glu-Val-Cit-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-Cit-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser-OH make it an attractive candidate for the design of peptide-based drug delivery systems. By leveraging its ability to form stable complexes with various cargos, researchers can explore strategies for targeted delivery and controlled release, enhancing the efficiency of experimental therapeutics and molecular probes.
Biosensor construction: Another significant application of this peptide lies in the development of biosensors for analytical detection of carbohydrates or proteins. Its sequence can be engineered to include recognition motifs that bind selectively to target analytes, enabling the creation of sensitive and specific detection platforms. Such biosensors are valuable in the monitoring of biological processes, environmental analysis, and quality control in biotechnological production. The versatility and customizable features of H-Glu-Val-Cit-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-Cit-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser-OH ensure its continued relevance in cutting-edge research, where it supports the advancement of peptide science, carbohydrate chemistry, and interdisciplinary investigations across the life sciences.
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