This is the 16 amino acid region of Antennapedia peptide (Penetratin) synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation studies, especially when studying attachment of peptide-like molecules to carriers.
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M.W/Mr. | 2503.1 |
Sequence | One Letter Code: C(Npys)-RQIKIWFQNRRMKWKK-NH2 Three Letter Code: H-C(Npys)Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2 |
References | Hodoniczky J. et al. Pep Sci. 90(5):595-603(2008). |
2. The spatiotemporal control of signalling and trafficking of the GLP-1R
3. Implications of ligand-receptor binding kinetics on GLP-1R signalling
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