DADLE is a prototypical δ-opioid receptor agonist that displays activity at the μ-opioid receptor and antinociceptive activity in vivo.
CAT No: R1886
CAS No:63631-40-3
Synonyms/Alias:DADLE;63631-40-3;H-TYR-D-ALA-GLY-PHE-D-LEU-OH;BW-180C;[D-Ala2, D-Leu5]-enkephalin;DADL;Enkephalin-leu,ala(2);2-Alanyl-leucine enkephalin;Leucine enkephalin-2-alanine;(D-Ala2,D-Leu5)-Enkephalin;5-Leucine-2-alanine enkephalin;ENKEPHALIN, LEUCINE-2-ALANINE;(D-Ala2,D-Leu5)enkephalin;H-Tyr-D-Ala-Gly-Phe-D-Leu;(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid;CQK2YXW6EZ;Tyr-D-Ala-Gly-Phe-D-Leu;CHEMBL340032;D-Leucine, N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-;L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine;[D-Ala2-D-Leu5]enkephalin;(D-Ala2, D-Leu5)-Enkephalin;(D-ALA2-D-LEU5)ENKEPHALIN;(2R,5S,11R,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid;Leu Enkephalin 2 Ala;Leu-Enkephalin-2-Ala;2 Alanyl Leucine Enkephalin;Leucine Enkephalin 2 Alanine;Leucine-2-Alanine Enkephalin;Enkephalin, 2-Alanyl-Leucine;Enkephalin, Leucine 2 Alanine;Enkephalin-2-Alanine, Leucine;5 Leucine 2 Alanine Enkephalin;Enkephalin, 5-Leucine-2-Alanine;D-Ala(2)-D-Leu(5)-Enkephalin;(2R)-2-(((2S)-2-((2-(((2R)-2-(((2S)-2-amino-3-(4-hydroxyphenyl)propanoyl)amino)propanoyl)amino)acetyl)amino)-3-phenylpropanoyl)amino)-4-methylpentanoic acid;DADLE-OH;UNII-HB4QD9GL6F;GTPL1607;SCHEMBL11124725;BDBM21025;AKOS024457800;DB08856;ENKEPHALIN-(2-D-ALA, 5-D-LEU);FA108791;TS-10506;HY-105343;CS-0025794;NS00071158;G77857;Q424905;TYROSYL-D-ALANYLGLYCYLPHENYLALANYL-D-LEUCINE;D-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-;H-Tyr-D-Ala-Gly-Phe-D-Leu-OH; H-Y(dA)GF(dL)-OH;(2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-methylpentanoic acid;
Chemical Name:(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
DADLE (D-Ala2, D-Leu5-Enkephalin) is a synthetic opioid peptide that serves as a selective agonist for the delta-opioid receptor. Structurally derived from the endogenous enkephalin family, DADLE is characterized by its resistance to enzymatic degradation and its high affinity for delta-type opioid receptors, distinguishing it from other opioid peptides. Its unique biochemical properties make it a valuable tool for probing opioid receptor pharmacology, signal transduction mechanisms, and neuropeptide function in a variety of research contexts. The ability of DADLE to modulate neuronal signaling and influence diverse physiological processes has established its significance in neuroscience, pharmacology, and peptide research.
Receptor Pharmacology: In receptor pharmacology studies, DADLE is widely employed to elucidate the function and signaling pathways of delta-opioid receptors. Its high selectivity allows researchers to distinguish delta-receptor-mediated effects from those mediated by mu or kappa opioid receptors. By utilizing DADLE in binding assays, second messenger studies, and receptor desensitization experiments, investigators can gain insights into receptor activation, downstream signaling cascades, and receptor-ligand interactions. Such research is fundamental for advancing the understanding of opioid receptor biology and for the development of more selective pharmacological probes.
Neuroscience Research: DADLE is extensively used in neuroscience to investigate the roles of endogenous opioid systems in modulating neuronal activity, synaptic transmission, and neuroprotection. Its application in electrophysiological recordings, neurochemical assays, and in vitro brain slice preparations enables the study of delta-opioid receptor function in central and peripheral nervous system tissues. These investigations contribute to a deeper comprehension of pain modulation, stress responses, and neuroplasticity, as well as the broader physiological impact of opioid peptides in the nervous system.
Peptide Structure-Activity Relationship Studies: As a synthetic analog of enkephalins, DADLE is instrumental in structure-activity relationship (SAR) studies aimed at optimizing peptide ligands for opioid receptors. By comparing the pharmacological properties of DADLE with other enkephalin derivatives and modified peptides, researchers can identify key structural features that govern receptor selectivity, potency, and metabolic stability. Insights gained from SAR analyses facilitate the rational design of novel peptide ligands with improved characteristics for research or industrial applications.
Signal Transduction Analysis: The use of DADLE in signal transduction studies enables the dissection of intracellular pathways activated by delta-opioid receptor engagement. Researchers employ this peptide in cell-based assays to monitor changes in cyclic AMP levels, protein phosphorylation, and G-protein coupling following receptor activation. These mechanistic studies are essential for mapping the downstream effects of delta-opioid receptor stimulation, providing a foundation for understanding how opioid peptides influence cellular function and communication.
Peptide Receptor Localization and Imaging: DADLE is also applied in studies aimed at localizing delta-opioid receptors within tissues and cellular compartments. By utilizing labeled or conjugated forms of the peptide, researchers can visualize receptor distribution through techniques such as autoradiography, immunohistochemistry, or fluorescence imaging. These approaches offer valuable information on the anatomical and cellular localization of delta-opioid receptors, supporting investigations into receptor function, tissue-specific expression, and the physiological relevance of opioid signaling pathways.
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