DAPTA

DAPTA, an analog of peptide T, acts as a chemokine receptor 5 (CCR5) antagonist that inhibits the entry of the virus. It is used potentially for the treatment of HIV infection and HBV infection.

Online Inquiry

Specification Technical Data Related Products Customer reviews and Q&A Useful Tools Publications

CAT#	R1013
CAS	106362-34-9
Background	DAPTA, a non-toxic experimental antiviral entry inhibitor, which is derived from the V2 region, near the stem of HIV-1SF-2 env protein (amino acids 185–192)blocks infection of R5 and dual tropic (R5/X4) HIV-1 strains in monocyte-derived macrophages, microglia and primary CD4+ T-cells and is an antagonist of CCR5-mediated chemotaxis. >> Read More
Synonyms/Alias	D-Alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-L-threoninamide
M.F/Formula	C35H56N10O15
M.W/Mr.	856.89
Sequence	H-D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2
Labeling Target	Chemokine receptor
Appearance	White lyophilised solid
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Antagonist

CAT#	Product Name	M.W	Molecular Formula	Inquiry
R0856	Compstatin control peptide	1488.67	C66H101N23O17	Inquiry
R0857	c-JUN peptide	2743.55	C121H210N36O34S	Inquiry
R0904	ZIP, Biotinylated	2154.69	C100H168N32O19S	Inquiry
R0933	st-Ht31 P	2766.19	C127H209N29O39	Inquiry
R0937	NFAT inhibitor, Cell Permeable	3573.15	C147H259N67O36S	Inquiry

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.

Source#	Synthetic
Storage	-20°C
Solubility	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C35H56N10O15/c1-13(36)29(54)41-22(12-46)32(57)43-26(16(4)49)34(59)45-27(17(5)50)35(60)44-25(15(3)48)33(58)40-21(11-23(37)52)30(55)39-20(10-18-6-8-19(51)9-7-18)31(56)42-24(14(2)47)28(38)53/h6-9,13-17,20-22,24-27,46-51H,10-12,36H2,1-5H3,(H2,37,52)(H2,38,53)(H,39,55)(H,40,58)(H,41,54)(H,42,56)(H,43,57)(H,44,60)(H,45,59)/t13-,14-,15-,16-,17-,20+,21+,22+,24+,25+,26+,27+/m1/s1
InChI Key	AKWRNBWMGFUAMF-ZESMOPTKSA-N
Isomeric SMILES	C[C@H]([C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@@H](C)N)O
ShelfLife	>2 years if stored properly
References	A pre-HAART era placebo-controlled trial showed that DAPTA caused cognitive improvements, and a later analysis of stored samples suggests a clinically significant reduction in plasma viral load (K. Goodkin, University of Miami, personal communication). A more recent uncontrolled clinical trial reports that DAPTA substantially suppressed virus in persistently infected cellular reservoirs in both HAART experienced and naïve to treatment patients. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)