DiaPep277 is a groundbreaking peptide-based therapeutic used in the treatment of type 1 diabetes. By targeting the immune system, DiaPep277 helps to modulate autoimmune responses, preserving and protecting insulin-producing cells. Its efficacy has been extensively studied and documented, making it a promising treatment option for patients with type 1 diabetes.
CAT No: R1980
CAS No:179822-83-4
Chemical Name:(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-4-carboxybutanoyl]amino]butanedioic acid
DiaPep277 is a synthetic peptide derived from the human heat shock protein 60 (Hsp60) sequence, specifically designed for research applications in immunology, peptide biology, and molecular signaling studies. As a structurally defined peptide fragment, it offers a unique tool for investigating the role of Hsp60-derived epitopes in immune modulation, T-cell response characterization, and peptide-major histocompatibility complex (MHC) interactions. Its relevance extends to studies focused on autoimmune mechanisms, antigen presentation, and the broader field of peptide-mediated cellular processes, making it a valuable resource for researchers exploring the interface between peptide structure and immunological function.
Immunological research: DiaPep277 provides a robust platform for dissecting peptide-specific immune responses, particularly in the context of T-cell activation and antigen recognition. By serving as a defined epitope, it enables the study of peptide-MHC binding dynamics and the subsequent signaling cascades that lead to immune cell activation or tolerance. Researchers utilize this peptide to model and analyze the molecular mechanisms underlying antigen-specific immune modulation, which is critical for understanding autoimmune pathogenesis and immune regulation at the cellular and molecular levels.
Autoimmunity mechanism studies: The peptide is frequently employed in research focused on the etiology and progression of autoimmune disorders, especially those involving aberrant T-cell reactivity to self-antigens. Its sequence, derived from Hsp60, allows scientists to evaluate how specific peptide fragments can influence the balance between immune tolerance and autoimmunity. By incorporating DiaPep277 into in vitro and in vivo experimental models, investigators can elucidate the pathways by which peptide antigens contribute to the breakdown of self-tolerance, providing insights into the triggers and progression of autoimmune phenomena.
Peptide-MHC interaction assays: DiaPep277 is an effective tool for studying the molecular interactions between peptide ligands and MHC class II molecules. Its defined structure supports detailed investigations into binding affinities, structural conformations, and the presentation of antigenic peptides to T-cell receptors. These studies are essential for mapping the specificity and diversity of immune recognition, as well as for identifying critical determinants of peptide immunogenicity. The peptide's application in these assays advances the understanding of antigen presentation mechanisms and aids in the development of peptide-based immunological models.
Peptide synthesis and analytical validation: As a well-characterized synthetic peptide, DiaPep277 serves as a reference standard in the optimization and validation of peptide synthesis protocols. Its use in analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry allows researchers to calibrate instrumentation, assess purity, and verify sequence fidelity in peptide production workflows. This supports quality control processes in both academic and industrial peptide research settings, ensuring the reliability and reproducibility of peptide-based experiments.
Cellular signaling pathway exploration: The peptide's ability to interact with specific immune cell receptors makes it a valuable agent for probing intracellular signaling pathways initiated by peptide-receptor engagement. Researchers apply DiaPep277 in cell-based assays to monitor downstream effects such as cytokine release, gene expression modulation, and cellular differentiation. These studies provide mechanistic insights into how defined peptide ligands can modulate immune cell behavior, contributing to the broader understanding of immune system regulation and peptide-driven cellular communication.
3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
5. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
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