3,5-Diiodo-D-thyronine is a halogenated, non-proteinogenic amino acid derivative related to thyroid hormone scaffolds, featuring the thyronine core with two iodine substituents at the 3- and 5-positions and a D-stereochemical configuration as indicated by the name. The molecule contains an amino group and a carboxyl group on the thyronine framework, while the iodinated aromatic rings provide strong electron-withdrawing functionality and a distinct mass/halogen signature for analytical detection. In research settings, it is used as a chemically defined iodinated amino acid analogue for structure-activity studies, chemical biology assays, and analytical method development where halogenated stereodefined targets and isotope/iodine-sensitive characterization are relevant.
CAT No: CP18302
3,5-Diiodo-D-thyronine is a iodinated thyronine derivative used as a thyroid hormone-related chemical building block and analytical reference. The D-configuration and the presence of two iodine atoms on the aromatic rings make it a structurally defined, isotope-sensitive reagent for studying iodine-containing hormone analogs and for supporting mass spectrometry workflows where iodine substitution patterns matter. In practice, it is handled as a research-grade small-molecule standard or intermediate rather than as a proteinogenic amino acid.
1. Thyroid Hormone Analog Studies
3,5-Diiodo-D-thyronine is used in chemical biology and endocrine research settings to create well-defined thyroid hormone analog panels for receptor-binding and ligand-displacement experiments in vitro. Researchers select this specific diiodinated thyronine scaffold to match the iodine substitution pattern that strongly influences physicochemical behavior and analytical detectability. The D-stereochemical form is commonly chosen when stereochemistry must be controlled for structure-activity relationship work, method validation, or comparative ligand studies across thyronine stereoisomers and iodination states.
2. LC-MS And GC-MS Standards
3,5-Diiodo-D-thyronine serves as a mass spectrometry reference compound for quantitative and qualitative analysis of iodinated thyronine species in complex matrices. Analytical teams rely on its defined iodine content to improve peak assignment confidence and to support calibration or confirmation strategies when monitoring thyroid-related metabolites, degradation products, or synthetic intermediates. This compound is frequently used by laboratories developing LC-MS/MS methods for iodine-containing hormone analogs, including workflows that require stable, non-radioactive standards for retention-time and fragment-ion matching.
3. Pharmaceutical Intermediate Development
3,5-Diiodo-D-thyronine is also applied as a defined starting material in pharmaceutical intermediate development and specialty chemical synthesis where iodinated thyronine motifs are required. Process and R&D chemists use it to build or benchmark downstream intermediates used in the preparation of thyroid hormone analogs and related chemical series for medicinal chemistry programs. Its rigid aromatic thyronine framework and fixed diiodination pattern make it a practical reference point for screening synthetic routes and for ensuring consistent composition during intermediate characterization and specification setting.
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