Ebiratide is a short regulatory peptide enriched with hydrophobic and polar residues supporting receptor-binding and structural studies. Researchers analyze its conformational behavior and solubility under varying pH. Sequence features promote flexible folding and interaction with cellular targets. Applications include peptide-signaling research, mechanistic modeling, and analog design.
CAT No: R2876
CAS No:105250-86-0
Synonyms/Alias:Ebiratide; 105250-86-0; Ebiratide [INN]; Ebiratidum; Ebiratida; CM5J1V7AUT; Ebiratidum [Latin]; Ebiratida [Spanish]; UNII-CM5J1V7AUT; DTXSID60883159; Ebiratidum (Latin); L-Methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-D-lysyl-N-(8-aminooctyl)-L-phenylalaninamide S,S-dioxide; Hoe 427; Met-O2-Glu-His-Phe-D-Lys-Phe-NH-(CH2)8-NH2; DTXCID801022716; (4S)-5-[[(2S)-1-[[(2S)-1-[[(2R)-6-amino-1-[[(2S)-1-(8-aminooctylamino)-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-amino-4-methylsulfonylbutanoyl]amino]-5-oxopentanoic acid; Hoe-427; (4S)-5-[[(2S)-1-[[(2S)-1-[[(2R)-6-amino-1-[8-aminooctyl-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-amino-4-methylsulfonylbutanoyl]amino]-5-oxopentanoic acid; SCHEMBL140882; Q27275529
Ebiratide is a synthetic peptide compound designed to mimic specific functional domains of naturally occurring proteins involved in cellular signaling and tissue repair. As a member of the peptide class, it is characterized by a precise amino acid sequence that confers unique biochemical properties, including the ability to interact with cell surface receptors and modulate intracellular pathways. The structural features of this peptide make it a valuable tool for researchers investigating mechanisms of cell communication, tissue regeneration, and peptide-receptor interactions. Its defined composition and reproducible activity support its use in a range of experimental settings, making it a significant asset in the field of peptide research and development.
Peptide signaling research: Ebiratide serves as a model system for studying peptide-mediated cellular signaling. Its sequence is engineered to engage with specific receptors, enabling researchers to dissect the downstream effects of ligand-receptor interactions in vitro. By using this compound, scientists can elucidate the pathways activated by peptide ligands, assess receptor specificity, and quantify the cellular responses triggered by such interactions. This capability is essential for advancing the understanding of signal transduction mechanisms and for screening potential modulators of peptide-based signaling cascades.
Receptor binding assays: The peptide is highly suitable for use in receptor binding studies, where its affinity and selectivity can be quantitatively evaluated against various target receptors. Through radioligand binding, fluorescence-based assays, or surface plasmon resonance, investigators can determine binding kinetics, receptor occupancy, and competitive inhibition profiles. Such applications are instrumental in characterizing novel receptors, validating target engagement, and supporting the early-phase screening of peptide analogs or antagonists in drug discovery research.
Cellular function modulation: Ebiratide provides a controlled means to modulate cellular functions in experimental models. Researchers employ it to induce or inhibit specific cellular processes, such as proliferation, migration, or differentiation, depending on the context of the study. By applying the peptide to cultured cells or tissue explants, investigators can monitor changes in gene expression, protein phosphorylation, or metabolic activity, thereby gaining insights into the biological consequences of targeted peptide interventions.
Peptide structure-activity relationship (SAR) studies: The defined sequence and known bioactivity of this compound make it a valuable reference in SAR investigations. By systematically modifying its amino acid composition or chemical modifications, scientists can map the structural determinants responsible for biological activity. These studies facilitate the rational design of next-generation peptide analogs with improved stability, potency, or selectivity, supporting both basic research and the development of peptide-based technologies.
Peptide synthesis and analytical method validation: Ebiratide is frequently utilized as a standard or reference material in the optimization of peptide synthesis protocols and the validation of analytical methods. Its well-characterized physicochemical properties enable laboratories to calibrate chromatographic systems, assess peptide purity, and verify method performance. This role is critical in ensuring the reliability and reproducibility of peptide production workflows, as well as in the quality control of research-grade peptide preparations.
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