Endothelin 1, human, porcine

Endothelin-1 is a 21 amino acid polypeptide with effective vasoconstriction. Activates phospholipase C in fibroblasts expressing ETA receptors. Endothelin-1 autocrine and paracrine signal transduction regulates cell proliferation, apoptosis, migration, and epithelial to mesenchymal transition, suggesting its role in cancer.

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CAT#R1818
CAS117399-94-7
Synonyms/AliasET-1, CSCSSLMDKECVYFCHLDIIW, Endothelin 1, Human and Porcine
M.F/FormulaC109H159N25O32S5
M.W/Mr.2491.9
SequenceOne Letter Code: CSCSSLMDLECVTPCHLDIIW
Three Letter Code: H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
AppearanceWhite to off-white solid
Purity≥98%
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