Endothelin-1 is a 21 amino acid polypeptide with effective vasoconstriction. Activates phospholipase C in fibroblasts expressing ETA receptors. Endothelin-1 autocrine and paracrine signal transduction regulates cell proliferation, apoptosis, migration, and epithelial to mesenchymal transition, suggesting its role in cancer.
CAT# | R1818 |
CAS | 117399-94-7 |
Synonyms/Alias | ET-1, CSCSSLMDKECVYFCHLDIIW, Endothelin 1, Human and Porcine |
M.F/Formula | C109H159N25O32S5 |
M.W/Mr. | 2491.9 |
Sequence | One Letter Code: CSCSSLMDLECVTPCHLDIIW Three Letter Code: H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11) |
Appearance | White to off-white solid |
Purity | ≥98% |
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