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Endothelin-1 is a 21 amino acid polypeptide with effective vasoconstriction. Activates phospholipase C in fibroblasts expressing ETA receptors. Endothelin-1 autocrine and paracrine signal transduction regulates cell proliferation, apoptosis, migration, and epithelial to mesenchymal transition, suggesting its role in cancer.
| CAT# | R1818 |
| CAS | 117399-94-7 |
| Synonyms/Alias | ET-1, CSCSSLMDKECVYFCHLDIIW, Endothelin 1, Human and Porcine |
| M.F/Formula | C109H159N25O32S5 |
| M.W/Mr. | 2491.9 |
| Sequence | One Letter Code: CSCSSLMDLECVTPCHLDIIW Three Letter Code: H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11) |
| Appearance | White to off-white solid |
| Purity | ≥98% |
| Source# | Synthetic | Length | 21 | Storage | Desiccate at -20°C | Solubility | Soluble to 1 mg/ml in water | Shipping Condition | Ship with RT , or blue ice upon request | InChI | 1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166) | InChI Key | ZUBDGKVDJUIMQQ-UHFFFAOYSA-N | Canonical SMILES | [H][C@](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@]2([H])CSSC[C@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N1)([C@@H](C)CC)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O | Modifications | disulfide |
| CAT# | Product Name | M.W | Molecular Formula | Inquiry |
|---|---|---|---|---|
| R0987 | PBP 10 | Inquiry | ||
| R1007 | Conantokin-T | Inquiry | ||
| R1938 | Dodecanedioic acid | Inquiry | ||
| R1387 | Gluten Exorphin B5 | Inquiry | ||
| R1583 | OVA Peptide 257-264 | Inquiry |
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