Etelcalcetide

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#10-101-140
Chemical Structure
ExplanationEtelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.
Synonyms/AliasVelcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163
M.F/FormulaC38H73N21O10S2
M.W/Mr.1048.26
SequenceThree Letter Code: H-Cys(1)-OH . Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2
ApplicationEtelcalcetide is a calcium-sensing receptor agonist that indicated for Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.
AppearanceSolid powder
ActivityActivator
Biological ActivityEtelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a synthetic octapeptide composed of a linear chain of seven d-amino acids with the N-terminal d-cysteine linked to an l-cysteine via a covalent disulfide bond.
TargetCaSR
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