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APIs

Etelcalcetide

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CAT#
10-101-140
Synonyms/Alias
Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163
CAS No.
1262780-97-1
Sequence
H-Cys(1)-OH . Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2
M.W/Mr.
1048.26
Molecular Formula
C38H73N21O10S2
Source
Synthetic
Description
Etelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.
Areas of Interest
Hyperparathyroidism
Storage
-20°C

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