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Etelcalcetide

CAT#

10-101-140

CAS No.

1262780-97-1

Description

Etelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.

Synonyms/Alias

Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163

Molecular Formula

C38H73N21O10S2

M.W/Mr.

1048.26

Sequence

H-Cys(1)-OH . Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2

Labeling Target

Extracellular calcium-sensing receptor

Application

Etelcalcetide is a calcium-sensing receptor agonist that indicated for Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Areas of Interest

Immunology & Inflammation
Cell Biology
Cancer

Functions

Phosphatidylinositol phospholipase c activity

Disease

Secondary hyperparathyroidism

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Etelcalcetide

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