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Etelcalcetide

CAT#

10-101-140

Synonyms/Alias

Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163

CAS No.

1262780-97-1

Sequence

H-Cys(1)-OH . Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2

M.W/Mr.

1048.26

Molecular Formula

C38H73N21O10S2

Source

Synthetic

Description

Etelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.

Areas of Interest

Hyperparathyroidism

Storage

-20°C

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