Etelcalcetide

Name: Etelcalcetide
Brand: Creative Peptides
SKU: 10-101-140
Availability: MadeToOrder

Etelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.

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CAT No: 10-101-140

CAS No: 1262780-97-1

Synonyms/Alias: etelcalcetide;Velcalcetide;1262780-97-1;Parsabiv;AMG-416;KAI-4169;Telcalcetide;Etelcalcetida;AMG 416;UNII-60ME133FJB;60ME133FJB;KAI 4169;ONO-5163;Amg416;DTXSID70155132;D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-, disulfide with L-cysteine;N-ACETYL-D-CYSTEINYL-D-ALANYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ALANYL-D-ARGININAMIDE DISULFIDE WITH L-CYSTEINE;Etelcalcetide [USAN:INN];Etelcalcetidum;ETELCALCETIDE [MI];ETELCALCETIDE [INN];Etelcalcetide (USAN/INN);ETELCALCETIDE [USAN];ETELCALCETIDE [WHO-DD];GTPL8375;CHEMBL3545184;DTXCID2077623;SCHEMBL21982605;H05BX04;KAI4169;CHEBI:134700;BDBM627976;GLXC-10160;ETELCALCETIDE [ORANGE BOOK];HY-P1955;AKOS037648615;Etelcalcetide Hydrochloride(AMG-416);DB12865;CVD-0019441;BS-14875;DA-50394;DA-63291;FE162097;CS-0030931;NS00127425;D10676;D71178;EN300-25975978;Q21098973;(2R)-2-amino-3-{[(2S)-2-{[(1R)-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}ethyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}ethyl]carbamoyl}-2-acetamidoethyl]disulfanyl}propanoic acid;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C38H73N21O10S2
M.W/Mr.	1048.3
Sequence	Three Letter Code:Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2.H-Cys(1)-OH
Application	Etelcalcetide is a calcium-sensing receptor agonist that indicated for Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.
Appearance	Solid powder
Activity	Activator
Biological Activity	Etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a synthetic octapeptide composed of a linear chain of seven d-amino acids with the N-terminal d-cysteine linked to an l-cysteine via a covalent disulfide bond.
Target	CaSR

Shipping Condition	Room temperature in continental US; may vary elsewhere.
InChI	InChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1
InChI Key	ANIAZGVDEUQPRI-ZJQCGQFWSA-N

1. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

2. Proinsulin C-peptide and insulin: Limited pattern similarities of interest in inter-peptide interactions but no C-peptide effect on insulin and IGF-1 receptor signaling

3. Multifunctional peptide-oligonucleotide conjugate promoted sensitive electrochemical biosensing of cardiac troponin I

4. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

5. Odorant binding protein based biomimetic sensors for detection of alcohols associated with Salmonella contamination in packaged beef

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