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Etelcalcetide

Etelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Etelcalcetide(CAS 1262780-97-1)

CAT No: 10-101-140

CAS No:1262780-97-1

Synonyms/Alias:etelcalcetide;Velcalcetide;1262780-97-1;Parsabiv;AMG-416;KAI-4169;Telcalcetide;Etelcalcetida;AMG 416;UNII-60ME133FJB;60ME133FJB;KAI 4169;ONO-5163;Amg416;DTXSID70155132;D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-, disulfide with L-cysteine;N-ACETYL-D-CYSTEINYL-D-ALANYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ALANYL-D-ARGININAMIDE DISULFIDE WITH L-CYSTEINE;Etelcalcetide [USAN:INN];Etelcalcetidum;ETELCALCETIDE [MI];ETELCALCETIDE [INN];Etelcalcetide (USAN/INN);ETELCALCETIDE [USAN];ETELCALCETIDE [WHO-DD];GTPL8375;CHEMBL3545184;DTXCID2077623;SCHEMBL21982605;H05BX04;KAI4169;CHEBI:134700;BDBM627976;GLXC-10160;ETELCALCETIDE [ORANGE BOOK];HY-P1955;AKOS037648615;Etelcalcetide Hydrochloride(AMG-416);DB12865;CVD-0019441;BS-14875;DA-50394;DA-63291;FE162097;CS-0030931;NS00127425;D10676;D71178;EN300-25975978;Q21098973;(2R)-2-amino-3-{[(2S)-2-{[(1R)-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}ethyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}ethyl]carbamoyl}-2-acetamidoethyl]disulfanyl}propanoic acid;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C38H73N21O10S2
M.W/Mr.
1048.3
Sequence
Three Letter Code:Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2.H-Cys(1)-OH
Application
Etelcalcetide is a calcium-sensing receptor agonist that indicated for Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.
Appearance
Solid powder
Activity
Activator
Biological Activity
Etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a synthetic octapeptide composed of a linear chain of seven d-amino acids with the N-terminal d-cysteine linked to an l-cysteine via a covalent disulfide bond.
Target
CaSR
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1
InChI Key
ANIAZGVDEUQPRI-ZJQCGQFWSA-N

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