Follicle Stimulating Hormone is a glycoprotein-derived peptide region featuring diverse polar and charged residues that enable complex folding. Researchers employ it to study conformational transitions, glycosylation-associated patterns, and ligand-binding interfaces. Its structural diversity supports mechanistic and biophysical research.
CAT No: R2332
CAS No:146479-72-3
Synonyms/Alias:Urofollitropin;97048-13-0;146479-72-3;Follicle-stimulating hormone;1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide;26995-91-5;Follicle stimulating hormone;Fertinex; Fertinorm; Metrodin; Orgafol; Urofollitrophin;DTXSID3040483;SCHEMBL19712185;DTXSID10869286;ZDRRIRUAESZNIH-UHFFFAOYSA-N;FSH (Follicle Stimulating Hormone);AT36867;FOLLICLE-STIMULATING HORMONE [MI];DA-78798;FOLLICLE STIMULATING HORMONE [VANDF];FOLLICLE STIMULATING HORMONE [GREEN BOOK];Q4006490;1-{19-Amino-7-(2-amino-2-oxoethyl)-13-(butan-2-yl)-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl}prolylleucylglycinamide;
Follicle Stimulating Hormone is a glycoprotein hormone that plays a central role in the regulation of reproductive processes in vertebrates. Biochemically, it is composed of two non-covalently linked subunits, alpha and beta, each contributing to its specific biological activity. As a critical component of the hypothalamic-pituitary-gonadal axis, this hormone is essential for the growth and maturation of ovarian follicles in females and for spermatogenesis in males. Its precise regulation and interaction with its receptor make it a valuable molecule for exploring endocrine signaling pathways and reproductive physiology in a variety of research models.
Endocrinology research: As a key regulator of gonadal function, Follicle Stimulating Hormone is extensively utilized in studies investigating the mechanisms of hormonal control within the reproductive axis. Researchers employ it to dissect the downstream effects of pituitary-derived hormones on ovarian follicle development, granulosa cell proliferation, and steroidogenesis. Its use enables detailed analysis of feedback mechanisms involving gonadotropin-releasing hormone, luteinizing hormone, and sex steroids, contributing to a comprehensive understanding of endocrine system dynamics.
Reproductive biology studies: The hormone serves as an indispensable tool in elucidating the molecular and cellular events underlying gametogenesis. In vitro and in vivo experiments frequently incorporate it to stimulate follicular growth or to promote spermatogenic progression, allowing scientists to model physiological and pathological states of reproductive tissues. Such investigations facilitate the identification of gene expression changes, signaling cascades, and cellular interactions essential for fertility and gonadal homeostasis.
Signal transduction analysis: Follicle Stimulating Hormone is widely applied in the exploration of receptor-mediated signaling pathways. Upon binding to its specific G protein-coupled receptor on target cells, it activates complex intracellular cascades involving cyclic AMP, protein kinase A, and downstream transcription factors. By employing this hormone in cell-based assays, researchers can systematically investigate the dynamics of receptor activation, desensitization, and the modulation of signaling networks relevant to reproductive endocrinology.
Biotechnology and assay development: The hormone is frequently incorporated into bioassays and immunoassays designed to measure gonadotropin activity or receptor function. Its defined biological activity and specificity make it a reliable standard for calibrating analytical platforms, validating antibody specificity, and optimizing assay sensitivity. Such applications are crucial in both basic research and in the development of diagnostic tools for reproductive health assessment.
Comparative physiology and evolutionary studies: Follicle Stimulating Hormone provides a unique resource for comparative investigations across species, enabling the study of conserved and divergent features of reproductive regulation. By examining its effects in different animal models, scientists can trace the evolutionary adaptations of hormonal control mechanisms and receptor interactions. These insights are valuable for broadening the understanding of reproductive strategies and endocrine evolution across taxa.
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