Galanin (1-19), human is the 1-19 fragment of the human galanin. Galanin (GAL) is a widely distributed neuropeptide with diverse biological effectsincluding modulation of hormone release, antinociception and modification of feeding behavior.
CAT No: R1371
CAS No:136005-51-1
Synonyms/Alias:Galanin (1-19) (human);136005-51-1;galanin(1-19) (human);Galanin(1-19)(human);GTPL6088;DA-73623;FG109604;H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-OH; H-GWTLNSAGYLLGPHAVGNH-OH;
Galanin (1-19), human is a synthetic peptide fragment that corresponds to the biologically active N-terminal region of the human galanin neuropeptide. As a member of the galanin peptide family, it plays a critical role in modulating diverse physiological processes, including neurotransmission, neuroendocrine signaling, and cellular communication within the central and peripheral nervous systems. The 1-19 fragment represents the conserved functional core of the full-length galanin molecule, making it a valuable tool for dissecting receptor interactions and downstream signaling pathways. Its biochemical relevance is underscored by its ability to selectively engage galanin receptors, thereby enabling precise investigations into the molecular mechanisms underlying galanin-mediated effects.
Neuroscience research: The peptide is extensively utilized in studies exploring the modulation of synaptic transmission and neuronal excitability. By acting as a ligand for galanin receptors, it facilitates the examination of peptide-mediated neurotransmitter release, synaptic plasticity, and neuronal survival. Researchers employ this fragment to delineate the specific receptor subtypes involved in central nervous system signaling and to map the distribution and function of galaninergic neurons in various brain regions.
Receptor pharmacology: Galanin (1-19), human serves as an essential probe for characterizing the pharmacological properties of galanin receptor subtypes, including GALR1, GALR2, and GALR3. Its high affinity and selectivity for these receptors allow for detailed analysis of receptor activation, desensitization, and downstream signaling cascades. This application is particularly valuable in screening receptor agonists or antagonists and in elucidating structure-activity relationships within the galanin peptide family.
Peptide structure-function studies: The defined sequence of the 1-19 fragment enables systematic investigations into the structural determinants of galanin's biological activity. By comparing its effects with those of full-length galanin or other truncated analogs, researchers can identify critical residues and motifs responsible for receptor binding and functional selectivity. Such studies contribute to a deeper understanding of peptide-receptor interactions and support rational design of novel analogs with tailored properties.
Signal transduction analysis: The peptide is frequently employed to investigate intracellular signaling pathways activated by galanin receptor engagement. Experimental applications include assessing changes in second messenger levels, such as cyclic AMP or calcium flux, and profiling downstream effectors involved in cell signaling networks. These studies provide mechanistic insights into how galaninergic signaling influences cellular responses in neuronal and non-neuronal systems.
Peptide synthesis and assay development: As a well-characterized standard, Galanin (1-19), human is widely used in the development and validation of analytical assays, including receptor binding assays, immunoassays, and mass spectrometry-based detection methods. Its defined sequence and bioactivity make it an ideal reference material for calibrating assay sensitivity, specificity, and reproducibility in both basic and applied research settings.
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