Galanin Receptor Ligand M35 is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human GalR1 and GalR2, respectively.
CAT No: R1373
CAS No:142846-71-7
Synonyms/Alias:Galanin-(1-13)-bradykinin-(2-9)-amide;M35 Peptide;142846-71-7;DTXSID20162199;Galanin (1-13)-Bradykinin (2-9) amide;L-Argininamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-;M35;M 35;M-35;DTXCID0084690;MFCD00237055;FM73474;Galanin(1-13)-bradykinin(2-9)amide;NCGC00167245-01;
Galanin Receptor Ligand M35 is a synthetic peptide designed to interact specifically with galanin receptors, a family of G protein-coupled receptors widely distributed throughout the central and peripheral nervous systems. As a chimeric peptide antagonist, M35 incorporates structural elements that enable it to modulate the activity of both GalR1 and GalR2 receptor subtypes with high affinity. This compound has become a valuable tool in neurobiology and receptor pharmacology, offering researchers a means to dissect the physiological and molecular roles of galaninergic signaling pathways. Its unique sequence and receptor selectivity make it particularly relevant for studies exploring neuropeptide function, synaptic modulation, and the intricate mechanisms underlying neurotransmission.
Receptor Pharmacology: M35 is extensively used in receptor binding assays and functional studies aimed at characterizing the pharmacological properties of galanin receptors. By selectively antagonizing galanin binding, it allows researchers to delineate the contribution of specific receptor subtypes to cellular signaling cascades. Studies utilizing this ligand can quantify receptor density, assess ligand-receptor interactions, and elucidate downstream effects of receptor modulation, thereby advancing our understanding of galaninergic systems in both physiological and pathological contexts.
Neuroscience Research: The peptide serves as a critical investigative tool in neurobiological experiments that seek to unravel the roles of galanin in neuronal signaling, synaptic plasticity, and neuroendocrine regulation. Its ability to inhibit endogenous galanin activity enables precise manipulation of neuronal circuits, facilitating the study of processes such as pain perception, feeding behavior, mood regulation, and neuroprotection. By using M35 in in vitro and in vivo models, researchers can generate targeted insights into the functional dynamics of galaninergic neurotransmission.
Peptide Structure-Activity Relationship Studies: M35 is instrumental in the field of peptide SAR analysis, where its chimeric sequence provides a platform for examining the structural determinants of receptor selectivity and antagonistic potency. Modifications of its amino acid composition or backbone can yield valuable information about the molecular interactions governing ligand-receptor specificity. Such studies inform the rational design of next-generation peptide ligands with tailored pharmacological profiles, supporting both basic research and applied drug discovery initiatives.
Signal Transduction Investigations: The compound is frequently employed to probe intracellular signaling pathways activated by galanin receptors. By blocking receptor-mediated G protein signaling, it enables the dissection of second messenger cascades, such as cyclic AMP modulation, phospholipase C activation, and downstream kinase phosphorylation events. These applications are crucial for mapping the molecular mechanisms by which galanin influences cellular physiology and for identifying potential intervention points within these pathways.
Behavioral and Functional Studies: In behavioral neuroscience, M35 is utilized to assess the physiological and behavioral outcomes of galanin receptor inhibition in animal models. Its administration can help isolate the specific contributions of galaninergic signaling to complex behaviors, including stress responses, learning and memory, and appetite regulation. By integrating this peptide into experimental protocols, scientists can achieve a more nuanced understanding of neuropeptide-driven processes and their broader implications for neural function and adaptation.
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