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Gap 27

Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Gap 27(CAS 198284-64-9)

CAT No: R1375

CAS No:198284-64-9

Synonyms/Alias:GAP 27;198284-64-9;GAP 27 acetate salt;DTXSID80432769;Gap27;MFCD11045577;Connexin mimetic peptide;Connexin43 mimetic peptide;Gap 27?;H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH;DTXCID50383597;SXRAPDIXXYFGJG-MDAHIHQXSA-N;AKOS024456622;DA-63699;FG110171;TS-10350;G13727;H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH; H-SRPTEKTIFII-OH;

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cGMP Peptide
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  • CMC information required for an IND
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M.F/Formula
C60H101N15O17
M.W/Mr.
1304.5
Sequence
One Letter Code:SRPTEKTIFII
Three Letter Code:H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH
Shipping Condition
Room temperature
InChI
InChI=1S/C60H101N15O17/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76/h12-14,19-20,31-35,37-42,44-48,76-78H,9-11,15-18,21-30,61-62H2,1-8H3,(H,66,82)(H,67,88)(H,68,81)(H,69,86)(H,70,84)(H,71,89)(H,72,87)(H,73,83)(H,74,85)(H,79,80)(H,91,92)(H4,63,64,65)/t31-,32-,33-,34+,35+,37-,38-,39-,40-,41-,42-,44-,45-,46-,47-,48-/m0/s1
InChI Key
SXRAPDIXXYFGJG-MDAHIHQXSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(C(C)CC)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)CC)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CO)N
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)N
References
Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561. Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap jun

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