GIP (human)

Gastric Inhibitory Peptide (GIP), human is thought to act as an inhibitor of gastric functions.

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CAT#R1092
Chemical Structure
CAS100040-31-1
M.F/FormulaC226H338N60O66S
M.W/Mr.4983.58
SequenceOne Letter Code: YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
Three Letter Code: Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln
AppearanceWhite lyophilized solid
Biological ActivityPotent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and displays mitogenic and antiapoptotic effects in pancreatic β-cells.
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