This GluR23Y peptide was used in ELISA cell-surface assay for the insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y prevented any insulin-induced reduction. The blockade of insulin action was observed when the GluR23Y peptide was delivered into neurons by fusing it to the membrane transduction domain of HIV-1.
Peptide Library Construction and Screening
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M.W/Mr. | 1092.2 |
Sequence | One Letter Code: YKEGYNVYG Three Letter Code: H-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH |
References | 1. Ahmadian, G. et al. EMBO J. 23, 1040 (2004), 2. Wang, D. et al. J. Biol. Chem. 279, 41267 (2004). |
3. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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