Goralatide is a regulatory peptide enriched with polar and charged residues that promote flexible secondary structures. The motif supports research into peptide-protein recognition, solvent-driven folding, and side-chain interaction mapping. Researchers apply it in conformation-dependent biophysical assays. Its architecture aids detailed structural investigations.
CAT No: R2224
CAS No:120081-14-3
Synonyms/Alias:Goralatide;seraspenide;120081-14-3;Ac-Ser-Asp-Lys-Pro;AcSDKP;Ac-SDKP;Goralatide [INN];acetyl-SDKP;Ac-Ser-Asp-Lys-Pro-OH;goralatida;acetyl-N-Ser-Asp-Lys-Pro;N-acetyl-Ser-Asp-Lys-Pro;acetyl-seryl-aspartyl-lysyl-proline;goralatidum;AcSDKP-NH2;NAcSerAspLysPro;Ac-Ser-Asp-Lys-Pro-NH2;DTXSID0057629;UNII-H041538E9P;n-acetyl-seryl-aspartyl-lysyl-proline;127103-11-1;H041538E9P;DTXCID1031418;CHEBI:191178;N-acetyl-L-Ser-L-Asp-L-Lys-L-Pro;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-4-hydroxy-4-oxobutanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid;N-Ac-Ser-Asp-Lys-Pro;acetyl-L-seryl-L-aspartyl-L-lysyl-L-proline;L-Proline, 1-(N2-(N-(N-acetyl-L-seryl)-L-alpha-aspartyl)-L-lysyl)-;1-(N(sup 2)-(N-(N-Acetyl-L-seryl)-L-alpha-aspartyl)-L-lysyl)-L-proline;N-acetyl-L-seryl-L-alpha-aspartyl-L-lysyl-L-proline;L-PROLINE, N-ACETYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-LYSYL-;MFCD00076849;1-(N(SUP 2)-(N-(N-ACETYL-L-SERYL)-L-.ALPHA.-ASPARTYL)-L-LYSYL)-L-PROLINE;Acetyl-serinyl-aspartyl-lysinyl-proline;(2S)-1-((2S)-2-(((2S)-2-(((2S)-2-acetamido-3-hydroxypropanoyl)amino)-4-hydroxy-4-oxobutanoyl)amino)-6-aminohexanoyl)pyrrolidine-2-carboxylic acid;acetyl-seryl-aspartyl-lysyl-prolinamide;SCHEMBL669284;CHEMBL420741;N-Acetyl-Ser-Asp-Lys-Pro-OH;GTPL10060;CHEBI:168934;Tox21_113896;NCGC00261976-01;DA-53676;FA108367;DB-214753;CAS-120081-14-3;NS00121933;Q27279387;L-PROLINE, N-ACETYL-L-SERYL-L-ALPHA-ASPARTYL-L-LYSYL-;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-4-hydroxy-4-oxobutanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylicacid;(S)-1-((S)-2-((S)-2-((S)-2-acetamido-3-hydroxypropanamido)-3-carboxypropanamido)-6-aminohexanoyl)pyrrolidine-2-carboxylic acid;
Goralatide is a synthetic peptide analog designed to mimic the biological activity of certain endogenous peptides involved in metabolic and physiological regulation. Characterized by its stable structure and enhanced receptor affinity, goralatide is widely recognized for its versatility in both basic and applied research contexts. Its unique sequence and conformational properties make it a valuable tool for investigating peptide-receptor interactions, as well as for the exploration of signaling pathways relevant to metabolic and endocrine systems. Researchers appreciate its solubility, ease of handling, and compatibility with a variety of experimental techniques, which collectively facilitate its integration into diverse laboratory workflows.
Metabolic Research: In metabolic studies, goralatide serves as a potent agent for probing the mechanisms underlying energy homeostasis and nutrient sensing. By acting on specific peptide receptors, it enables scientists to delineate the signaling cascades that regulate glucose uptake, lipid metabolism, and overall energy expenditure. Through in vitro assays and animal models, researchers use this peptide to map out the physiological roles of peptide hormones, thereby advancing the understanding of metabolic disorders and the development of novel intervention strategies.
Endocrine System Investigations: Goralatide is instrumental in the analysis of hormonal regulation within the endocrine system. Its ability to selectively bind to peptide hormone receptors allows for precise evaluation of receptor dynamics, ligand specificity, and downstream effects. Experimental protocols frequently employ this peptide to dissect feedback loops and cross-talk between different hormonal axes, providing insights into the complexities of endocrine signaling and its implications in health and disease.
Pharmacological Screening: As a receptor agonist, goralatide is frequently utilized in pharmacological screening platforms to identify and characterize novel modulators of peptide receptor activity. High-throughput screening assays incorporate this analog to benchmark the efficacy and selectivity of candidate compounds, facilitating the discovery of new molecules with therapeutic potential. Its reproducible activity profile ensures consistent results, making it a preferred standard in competitive binding and functional response assays.
Signal Transduction Studies: In the context of cellular signaling, goralatide is a valuable molecular probe for dissecting intracellular pathways initiated by peptide receptor activation. Researchers leverage its defined mechanism of action to trace phosphorylation events, second messenger generation, and gene expression changes following receptor engagement. Such studies contribute to the broader understanding of how extracellular signals are transduced into cellular responses, informing both basic biology and translational research efforts.
Molecular Modeling and Structure-Activity Relationship (SAR) Analysis: The well-characterized structure of goralatide makes it an ideal candidate for computational modeling and SAR studies. Scientists employ this peptide to refine molecular docking algorithms, validate predictive models of receptor-ligand interactions, and guide the rational design of improved analogs. These efforts not only deepen knowledge of peptide-receptor recognition but also support the development of next-generation biomolecules with enhanced properties for research and beyond. Through these diverse applications, goralatide continues to enable scientific advancements across multiple disciplines, reinforcing its status as a cornerstone reagent in peptide research.
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