Goralatide is a regulatory peptide enriched with polar and charged residues that promote flexible secondary structures. The motif supports research into peptide-protein recognition, solvent-driven folding, and side-chain interaction mapping. Researchers apply it in conformation-dependent biophysical assays. Its architecture aids detailed structural investigations.
CAT No: R2224
CAS No:120081-14-3
Synonyms/Alias:Goralatide;seraspenide;120081-14-3;Ac-Ser-Asp-Lys-Pro;AcSDKP;Ac-SDKP;Goralatide [INN];acetyl-SDKP;Ac-Ser-Asp-Lys-Pro-OH;goralatida;acetyl-N-Ser-Asp-Lys-Pro;N-acetyl-Ser-Asp-Lys-Pro;acetyl-seryl-aspartyl-lysyl-proline;goralatidum;AcSDKP-NH2;NAcSerAspLysPro;Ac-Ser-Asp-Lys-Pro-NH2;DTXSID0057629;UNII-H041538E9P;n-acetyl-seryl-aspartyl-lysyl-proline;127103-11-1;H041538E9P;DTXCID1031418;CHEBI:191178;N-acetyl-L-Ser-L-Asp-L-Lys-L-Pro;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-4-hydroxy-4-oxobutanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid;N-Ac-Ser-Asp-Lys-Pro;acetyl-L-seryl-L-aspartyl-L-lysyl-L-proline;L-Proline, 1-(N2-(N-(N-acetyl-L-seryl)-L-alpha-aspartyl)-L-lysyl)-;1-(N(sup 2)-(N-(N-Acetyl-L-seryl)-L-alpha-aspartyl)-L-lysyl)-L-proline;N-acetyl-L-seryl-L-alpha-aspartyl-L-lysyl-L-proline;L-PROLINE, N-ACETYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-LYSYL-;MFCD00076849;1-(N(SUP 2)-(N-(N-ACETYL-L-SERYL)-L-.ALPHA.-ASPARTYL)-L-LYSYL)-L-PROLINE;Acetyl-serinyl-aspartyl-lysinyl-proline;(2S)-1-((2S)-2-(((2S)-2-(((2S)-2-acetamido-3-hydroxypropanoyl)amino)-4-hydroxy-4-oxobutanoyl)amino)-6-aminohexanoyl)pyrrolidine-2-carboxylic acid;acetyl-seryl-aspartyl-lysyl-prolinamide;SCHEMBL669284;CHEMBL420741;N-Acetyl-Ser-Asp-Lys-Pro-OH;GTPL10060;CHEBI:168934;Tox21_113896;NCGC00261976-01;DA-53676;FA108367;DB-214753;CAS-120081-14-3;NS00121933;Q27279387;L-PROLINE, N-ACETYL-L-SERYL-L-ALPHA-ASPARTYL-L-LYSYL-;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-4-hydroxy-4-oxobutanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylicacid;(S)-1-((S)-2-((S)-2-((S)-2-acetamido-3-hydroxypropanamido)-3-carboxypropanamido)-6-aminohexanoyl)pyrrolidine-2-carboxylic acid;
Goralatide is a synthetic peptide compound designed to mimic or modulate specific biological activities associated with peptide hormones and signaling molecules. As a member of the peptide class, it features a defined amino acid sequence that enables targeted interactions with particular cellular receptors or enzymes, making it a valuable tool in biochemical and pharmacological research. Its structural and functional properties allow researchers to investigate mechanisms of peptide-receptor binding, intracellular signaling cascades, and the broader physiological roles of bioactive peptides. The ability to synthesize Goralatide with high sequence fidelity further enhances its utility in experimental systems where reproducibility and specificity are critical.
Receptor Binding Studies: Goralatide is frequently employed in receptor-ligand interaction assays aimed at elucidating the binding dynamics between peptide ligands and their cognate receptors. By using radiolabeled or fluorescently tagged forms, researchers can quantitatively assess affinity, specificity, and kinetics of receptor engagement. These studies are essential for mapping receptor distribution, identifying novel peptide targets, and characterizing the molecular basis of signal transduction pathways. Such insights are instrumental in advancing the understanding of peptide-mediated cellular communication and in validating new targets for subsequent drug discovery efforts.
Cell Signaling Pathway Analysis: The peptide serves as a functional probe for dissecting intracellular signaling events triggered by peptide-receptor activation. Upon binding to its target receptor, Goralatide can induce or modulate downstream cascades, including second messenger generation, kinase activation, or gene transcription. Experimental use in cultured cells or cell-free systems enables detailed examination of these pathways, helping to clarify the roles of specific signaling nodes and cross-talk between pathways. This application is especially valuable for researchers investigating the physiological relevance of peptide signaling in health and disease models.
Peptide Structure-Activity Relationship (SAR) Studies: Goralatide provides a robust platform for systematic structure-activity relationship investigations. By introducing targeted modifications to its amino acid sequence or chemical backbone, scientists can evaluate how structural changes influence biological activity, stability, and receptor selectivity. These SAR studies inform the rational design of next-generation peptide analogs with enhanced potency, selectivity, or resistance to enzymatic degradation. Such efforts are central to the development of peptide-based research tools and the optimization of lead compounds for further preclinical evaluation.
Peptide Synthesis and Analytical Method Development: As a well-characterized synthetic peptide, Goralatide is valuable for benchmarking and validating peptide synthesis protocols and analytical methods. Laboratories engaged in solid-phase peptide synthesis or chromatographic purification can use it as a reference standard to assess yield, purity, and sequence fidelity. Additionally, its defined structure makes it suitable for calibrating mass spectrometry, HPLC, and other analytical platforms, supporting quality assurance and method development activities in both academic and industrial settings.
In vivo and in vitro Functional Assays: Goralatide is utilized in a range of functional assays to evaluate its biological effects in both cellular and organismal models. Researchers can administer the peptide to cultured cells, tissue preparations, or model organisms to observe physiological or biochemical responses, such as changes in signaling activity, gene expression, or metabolic profiles. These functional studies provide critical data on the peptide's mode of action, efficacy, and potential off-target effects, thereby informing broader investigations into peptide biology and the development of novel research reagents.
2. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
3. Emu oil in combination with other active ingredients for treating skin imperfections
4. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More