Guanylin (human) is a cysteine-rich peptide containing two disulfide bonds that stabilize β-sheet-like architecture. The sequence supports studies of redox behavior, folding pathways, and metal interactions. Researchers examine its conformational shifts and receptor-binding motifs. Its structural rigidity makes it suitable for detailed biophysical mapping.
CAT No: R2228
CAS No:183200-12-6
Synonyms/Alias:Guanylin (human);183200-12-6;Guanylin(human);Guanylin, human;MFCD00187933;AKOS024456838;DA-73944;FG108840;PD079197;H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH; H-PGTCEICAYAACTGC-OH;
Guanylin (human) is a bioactive peptide belonging to the guanylin family, recognized for its unique role in cellular signaling and homeostatic regulation within the gastrointestinal tract. Structurally, it is a small, secreted peptide that interacts with specific membrane receptors, triggering intracellular cascades that influence physiological processes. Its endogenous presence in the human body and its ability to modulate cyclic guanosine monophosphate (cGMP) production have made it a valuable molecule for researchers investigating intestinal function, fluid balance, and related signaling pathways. The molecular characteristics of Guanylin (human) allow for precise experimental manipulations, making it a preferred choice for in vitro and in vivo studies focused on epithelial cell biology and signal transduction.
Intestinal Physiology Research: Scientists employ Guanylin (human) to investigate mechanisms regulating electrolyte and water transport across the intestinal epithelium. By activating guanylate cyclase-C receptors on epithelial cells, it stimulates cGMP-dependent pathways, thereby modulating chloride and bicarbonate secretion. These actions are crucial for understanding the maintenance of fluid homeostasis in the gut, providing insights into the physiological basis of processes such as secretion and absorption. Experimental models using this peptide help delineate the molecular underpinnings of normal and dysregulated intestinal transport, supporting foundational research in gastrointestinal biology.
Signal Transduction Studies: The peptide is widely utilized in elucidating the intricacies of cGMP-mediated signaling pathways. Its ability to selectively activate guanylate cyclase-C makes it an indispensable tool for mapping downstream signaling events, including protein kinase activation and ion channel modulation. Researchers leverage this property to dissect the roles of secondary messengers in cellular communication, unraveling the complexities of intracellular signaling networks. Such studies are instrumental in expanding our understanding of how cells transduce extracellular signals into specific physiological responses.
Epithelial Cell Differentiation: Guanylin analogs and related peptides are frequently used to study their effects on epithelial cell proliferation and differentiation. By modulating signaling pathways essential for maintaining epithelial integrity, these compounds offer insights into the regulation of cell renewal and tissue homeostasis. Investigations in this area contribute to the broader field of regenerative medicine and tissue engineering, where understanding the cues that govern cell fate decisions is essential for developing novel therapeutic strategies and biomaterials.
Microbiome-Host Interactions: Research into the interplay between the gut microbiome and host physiology often incorporates guanylin peptides to explore how microbial metabolites influence host signaling pathways. The modulation of guanylate cyclase-C by endogenous and exogenous factors provides a platform for studying the bidirectional communication between microbes and epithelial cells. These experiments shed light on the mechanisms by which microbial communities impact host health, supporting the development of targeted approaches to modulate the microbiota-gut axis.
Preclinical Pharmacology Models: The use of Guanylin (human) in preclinical models enables the evaluation of novel compounds targeting guanylate cyclase-C or related pathways. By serving as a reference ligand or functional agonist, it facilitates the screening of candidate molecules for their efficacy and specificity in modulating cGMP-dependent responses. Such assays are critical for advancing the discovery of new agents that may influence gastrointestinal physiology or related signaling mechanisms, supporting the broader field of pharmacological research and drug development.
Peptide Structure-Function Analysis: Researchers utilize Guanylin (human) in structure-activity relationship studies to elucidate the molecular determinants responsible for receptor binding and activation. Through systematic modifications and comparative analyses, it is possible to map critical residues involved in peptide-receptor interactions. These investigations not only deepen our knowledge of peptide ligand biology but also guide the rational design of novel analogs with enhanced selectivity or stability, driving progress in peptide-based research and therapeutic innovation.
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