H-Tyr-Phe-Met-Arg-Phe-NH2 is a pentapeptide rich in aromatic and basic residues, forming diverse secondary-structure tendencies. The amidated C-terminus improves backbone stability and reduces terminal flexibility. Researchers use it to probe hydrophobic clustering, ligand recognition, and enzymatic susceptibility. Its defined motif supports biophysical and structural studies.
CAT No: 10-101-308
CAS No:99414-63-8
Synonyms/Alias:H-TYR-PHE-MET-ARG-PHE-NH2;99414-63-8;Tyr-Phe-Met-Arg-Phe-NH2;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide;(S)-N-((S)-1-Amino-1-oxo-3-phenylPropan-2-yl)-2-((S)-2-((S)-2-((S)-2-amino-3-(4-hydroxyphenyl)Propanamido)-3-phenylPropanamido)-4-(methylthio)butanamido)-5-guanidinopentanamide;
Chemical Name:(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
H-Tyr-Phe-Met-Arg-Phe-NH2, also recognized as a synthetic pentapeptide, is a carefully engineered carbohydrate compound designed for advanced research applications. Characterized by its unique amino acid sequence, this peptide offers versatility in various biochemical and molecular biology studies. Its structure enables targeted interaction with specific biomolecules, making it a valuable tool in exploring cellular processes and signaling pathways. Researchers appreciate its stability and compatibility with a range of experimental protocols, allowing for reproducible results and streamlined integration into existing workflows. The peptide's amide-capped C-terminus further enhances its biochemical properties, supporting its use in both in vitro and in vivo model systems for academic and industrial research.
Receptor Binding Studies: H-Tyr-Phe-Met-Arg-Phe-NH2 finds significant utility in receptor binding assays, where its sequence is designed to mimic endogenous ligands or signaling molecules. By introducing this peptide into cellular assays, scientists can investigate the affinity and specificity of receptor-ligand interactions, contributing to the mapping of receptor profiles and the identification of novel binding sites. This approach is instrumental in elucidating the mechanisms of signal transduction and in the development of targeted molecular probes for research purposes.
Cell Signaling Pathway Analysis: In the context of intracellular signaling, this pentapeptide serves as a valuable probe for dissecting complex biochemical cascades. By modulating the activity of specific signaling pathways, researchers can observe downstream effects and gain insights into the regulation of cellular responses. The peptide's ability to selectively interact with signaling proteins aids in the identification of key molecular switches, advancing our understanding of cellular communication and the intricate networks that govern physiological processes.
Enzyme Substrate Characterization: The sequence of H-Tyr-Phe-Met-Arg-Phe-NH2 renders it an effective substrate for proteolytic enzyme studies. Researchers utilize this compound to monitor enzyme kinetics, substrate specificity, and catalytic efficiency in controlled experimental settings. By tracking the cleavage or modification of the peptide, it becomes possible to characterize enzyme activity profiles and to screen for potential enzyme inhibitors or activators, which are crucial steps in drug discovery and biochemical research.
Peptide-Protein Interaction Mapping: As a synthetic analog, this pentapeptide is frequently employed in studies focused on mapping peptide-protein interactions. Its defined structure allows for systematic investigation of binding motifs and interaction domains within larger protein complexes. By labeling or modifying the peptide, scientists can track its association with target proteins, facilitating the identification of critical contact points and the development of interaction models that inform the design of new biomolecular tools.
Biomarker Discovery Research: H-Tyr-Phe-Met-Arg-Phe-NH2 plays a pivotal role in the search for novel biomarkers by serving as a reference molecule in comparative analyses. When introduced into biological samples, it can help differentiate between normal and altered states by acting as a control or standard in proteomic and metabolomic studies. This application supports the identification of unique molecular signatures associated with specific physiological or pathological conditions, thereby expanding the toolkit available for biomarker validation and translational research. Through these diverse research directions, the pentapeptide continues to advance scientific discovery across multiple disciplines, offering robust and reliable performance in experimental design and implementation.
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