Hirugen is a short peptide derived from hirudin that mimics a thrombin-binding exosite in biochemical assays. Acidic and aromatic residues create a complementary surface for thrombin recognition. Researchers use it to dissect exosite-mediated interactions and to build competition models. Applications include enzyme-surface mapping, inhibitor design, and coagulation-biology research.
CAT No: R2583
CAS No:121822-23-9
Synonyms/Alias:121822-23-9;Hirudin dodecapeptide;63-O-Sulfo-tyr-hirudin (53-64);BG 8865;Hirudin (53-64), O-sulfo-tyr(63)-;Hirudin (53-64), O-sulfotyrosine(63)-;BG8865;BG-8865;DTXSID30153376;NH2-Asn-gly-asp-phe-glu-glu-ile-pro-glu-glu-(SO3)tyr-leu-cooh;Asparaginyl-glycyl-aspartyl-phenylalanyl-glutamyl-glutamyl-isoleucyl-prolyl-glutamyl-glutamyl-O-sulfotyrosyl-leucine;L-Leucine, N-(N-(N-(N-(1-(N-(N-(N-(N-(N-(N-L-asparaginylglycyl)-L-alpha-aspartyl)-L-phenylalanyl)-L-alpha-glutamyl)-L-alpha-glutamyl)-L-isoleucyl)-L-prolyl)-L-alpha-glutamyl)-L-alpha-glutamyl)-O-sulfo-L-tyrosyl)-;DTXCID0075867;DA-54008;
2. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
5. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
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