Hyaluronan-Binding Peptide, biotin labeled

This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: C15019

Custom Peptide Synthesis

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.W/Mr.

2012.4

Sequence

One Letter Code: GAHWQFNALTVRGGGS-K(Biotin)
Three Letter Code: H-Gly-Ala-His-Trp-Gln-Phe-Asn-Ala-Leu-Thr-Val-Arg-Gly-Gly-Gly-Ser-Lys(Biotin)-OH

References

1. Mahaffey, C. and ME Mummert. J Immunol 179, 8191 (2007);
2. Mummert, M. et al. J Exp Med 192, 769 (2000).

1. Myotropic activity of allatostatins in tenebrionid beetles

2. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review

3. Proinsulin C-peptide and insulin: Limited pattern similarities of interest in inter-peptide interactions but no C-peptide effect on insulin and IGF-1 receptor signaling

4. The effect of B-type allatostatin neuropeptides on crosstalk between the insect immune response and cold tolerance

5. The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

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