(Hyp3)-Bradykinin

(Hyp3)-Bradykinin is a modified bradykinin peptide where the proline at position 3 is hydroxylated. This change enhances the peptide's stability and affinity for bradykinin receptors, which are involved in vasodilation and inflammatory processes. It is widely used in vascular research and studies of inflammatory signaling pathways, focusing on its potential effects on blood pressure regulation and tissue edema.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
(Hyp3)-Bradykinin(CAS 37642-65-2)

CAT No: B09039

CAS No:37642-65-2

Synonyms/Alias:Bradykinin hydroxyproline;37642-65-2;[Hyp3]-Bradykinin;[Hyp3]bradykinin;Arg-3-hyp-bradykinin;3-Hydroxy-pro-bradykinin;3-(L-4-Hydroxyproline)bradykinin;hydroxy-pro(3)-Bradykinin;Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg;hydroxyproline(3)-Bradykinin;(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid;Bradykinin, hydroxy-pro(3);Bradykinin, arg-hyp(3)-;[Hyp(3)]-bradykinin;arg-hyp(3)-Bradykinin;bradykinin hydroxy-pro(3);Bradykinin, hydroxy-pro(3)-;Bradykinin, hydroxyproline(3)-;CHEBI:133051;HY-P3061;AKOS015903400;[Hyp3]-Bradykinin, >=97% (HPLC);DA-48940;CS-0144127;G90940;L-Arg-L-Pro-L-Hyp-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg;(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S,4R)-1-{[(2S)-1-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanoyl]pyrrolidin-2-yl]carbonyl}-4-hydroxypyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-[(diaminomethylidene)amino]pentanoic acid;L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine;

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C50H73N15O12
M.W/Mr.
1076.2
Sequence
One Letter Code:RPXGFSPFR
Three Letter Code:H-Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg-OH
Source#
Synthetic
InChI
InChI=1S/C50H73N15O12/c51-32(15-7-19-56-49(52)53)45(73)64-22-10-18-38(64)47(75)65-27-31(67)25-39(65)43(71)58-26-40(68)59-34(23-29-11-3-1-4-12-29)41(69)62-36(28-66)46(74)63-21-9-17-37(63)44(72)61-35(24-30-13-5-2-6-14-30)42(70)60-33(48(76)77)16-8-20-57-50(54)55/h1-6,11-14,31-39,66-67H,7-10,15-28,51H2,(H,58,71)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,76,77)(H4,52,53,56)(H4,54,55,57)/t31-,32+,33+,34+,35+,36+,37+,38+,39+/m1/s1
InChI Key
JXRLHZCEMXTCBN-DIBGMJQNSA-N

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