iRGD Line Peptide incorporates the RGD and CendR motifs in a linear format, supporting integrin binding followed by neuropilin-associated transport studies. Alternating charged and hydrophobic residues guide receptor engagement and tissue penetration. Researchers evaluate its behavior in cell-binding and permeability models. Applications include targeted-delivery research, tumor-penetration studies, and receptor-motif engineering.
CAT No: R2582
CAS No:1184942-85-5
Synonyms/Alias:iRGD line peptide;EX-A9233;1184942-85-5;
iRGD line peptide is a synthetic peptide designed to facilitate targeted delivery and enhanced tissue penetration in biochemical and molecular research. Characterized by its internalizing RGD (Arg-Gly-Asp) motif, this peptide exhibits a unique capacity to interact with integrins and neuropilin-1 receptors, making it especially valuable for studies focusing on cellular uptake mechanisms and tissue-specific targeting. Its sequence and structural features allow for the exploration of receptor-mediated internalization pathways, offering researchers a powerful tool for probing the intricacies of cell adhesion, migration, and molecular transport across biological barriers. As a result, iRGD line peptide has become an important reagent in the investigation of cellular microenvironments and the development of advanced delivery systems in preclinical settings.
Targeted delivery research: In the context of targeted delivery studies, the iRGD line peptide is frequently employed to investigate mechanisms by which molecules or nanoparticles are selectively directed to specific cell types or tissues. Its RGD motif enables binding to αv integrins, which are commonly overexpressed on the surface of certain cell populations, such as endothelial and tumor cells in experimental models. By leveraging this specificity, scientists can assess the efficiency and selectivity of ligand-mediated targeting strategies and optimize carrier systems for improved localization and reduced off-target effects in a variety of in vitro and in vivo research frameworks.
Cellular penetration studies: The iRGD sequence is notable for its capacity to promote trans-tissue and transcellular transport, a property that is harnessed in studies aiming to understand and enhance tissue penetration of macromolecules. Through its interaction with neuropilin-1 following proteolytic cleavage, the peptide facilitates the internalization and deep tissue distribution of conjugated compounds or co-administered molecules. Researchers utilize this property to model and quantify the penetration of experimental agents across cellular barriers, providing critical insights into the determinants of tissue accessibility and the design of more effective delivery vehicles.
Receptor binding assays: The well-defined interaction profile of the iRGD line peptide with integrins and neuropilin-1 makes it an excellent probe in receptor binding and competition assays. By using labeled or functionalized versions of the peptide, investigators can map receptor distribution, quantify binding affinities, and study competitive inhibition among various ligands. These assays are essential for elucidating the molecular basis of receptor-ligand specificity, informing the rational design of new targeting motifs, and validating the biological relevance of integrin and neuropilin-1 in diverse cellular contexts.
Peptide-functional studies: As a model system for peptide-mediated biological functions, this compound supports a wide range of experimental applications such as the investigation of cell adhesion, migration, and signaling pathways. The iRGD motif's capacity to engage with cellular receptors provides a controlled platform for dissecting the downstream effects of integrin activation and the resultant intracellular signaling cascades. Such studies are critical for advancing the understanding of cell-matrix interactions, cytoskeletal dynamics, and the regulatory mechanisms underlying tissue remodeling and cellular communication.
Conjugation and delivery system development: The unique properties of the iRGD line peptide have positioned it as a valuable component in the development of advanced delivery systems for research applications. Its ability to be conjugated to a variety of molecular cargos—including proteins, nucleic acids, and nanoparticles—enables the creation of multifunctional constructs with enhanced targeting and penetration capabilities. Researchers employ it in the design and optimization of experimental delivery vehicles, evaluating parameters such as stability, bioavailability, and payload release in controlled environments. These efforts contribute to the refinement of delivery strategies for investigational compounds and the broader field of targeted molecular transport.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More