Isoleucyl-lysyl-valyl-alanyl-valine blends hydrophobic residues with a basic lysine, forming a sequence that highlights charge-hydrophobic balance. The peptide supports exploration of secondary-structure initiation and intermolecular association. Researchers assess its hydrogen-bond patterns in varied environments. Applications include motif analysis, peptide assembly research, and folding studies.
CAT No: R2471
CAS No:131167-89-0
Synonyms/Alias:131167-89-0;IKVAV;Ile-lys-val-ala-val;H-Ile-Lys-Val-Ala-Val-OH;Isoleucyl-lysyl-valyl-alanyl-valine;L-Valine,L-isoleucyl-L-lysyl-L-valyl-L-alanyl-;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid;SCHEMBL180642;CHEMBL1904201;DTXSID40927101;HY-P4322;N-(N-(N-(N(2)-L-Isoleucyl-L-lysyl)-L-valyl)-L-alanyl)-L-valine;NCGC00167208-01;DA-74166;CS-0653507;H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt;L-Valine, N-(N-(N-(N(2)-L-isoleucyl-L-lysyl)-L-valyl)-L-alanyl)-;N-(2-{[2-({6-Amino-2-[(2-amino-1-hydroxy-3-methylpentylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxy-3-methylbutylidene]amino}-1-hydroxypropylidene)valine;
Isoleucyl-lysyl-valyl-alanyl-valine, also known as IKVAV peptide, is a synthetic pentapeptide sequence derived from the laminin α1 chain, recognized for its significant role in modulating cellular behaviors. As a bioactive motif, IKVAV exhibits strong cell adhesion properties and interacts specifically with integrin receptors, facilitating essential processes such as cell differentiation, migration, and neurite outgrowth. Its unique amino acid arrangement imparts a high degree of biological activity, making it a valuable compound for researchers focused on extracellular matrix (ECM) biology and biomaterials engineering. The peptide's solubility and stability further enhance its utility in a variety of in vitro and in vivo experimental settings, supporting its integration into hydrogels, scaffolds, and surface coatings for advanced biomedical research.
Tissue Engineering: IKVAV peptide is widely employed in tissue engineering applications due to its capacity to promote cell attachment and guide cellular organization on biomaterial surfaces. When incorporated into synthetic scaffolds, it mimics the natural ECM environment, enhancing the biocompatibility and bioactivity of the materials. This enables more efficient cell seeding, proliferation, and differentiation, which are critical for the successful regeneration of tissues such as nerve, muscle, and cartilage. By providing specific biochemical cues, the pentapeptide supports the formation of functional tissue constructs that closely resemble native structures, thereby accelerating the development of engineered tissues for research and therapeutic exploration.
Neural Regeneration Research: In the context of neural regeneration, the IKVAV sequence has garnered attention for its remarkable ability to stimulate neurite extension and support neuronal survival. When immobilized onto substrates or incorporated into injectable hydrogels, it creates a permissive microenvironment that encourages neural cell adhesion and axonal growth. Researchers utilize this property to investigate mechanisms underlying nerve repair and to develop experimental models that emulate neural tissue architecture. The peptide's interaction with neural cells not only facilitates the study of neurodevelopmental processes but also aids in the design of biomimetic materials for neural tissue engineering.
Stem Cell Differentiation: The influence of the IKVAV motif extends to stem cell biology, where it serves as a potent inducer of lineage-specific differentiation. By presenting the peptide on culture surfaces or within three-dimensional matrices, scientists can direct stem cell fate decisions towards neuronal or other specialized cell types. This targeted differentiation is mediated by the activation of integrin signaling pathways, which are essential for cellular communication and morphogenesis. Such applications are instrumental in generating homogeneous populations of differentiated cells for fundamental research, drug screening, and regenerative medicine studies.
Cell Adhesion Studies: The pentapeptide is a valuable tool for dissecting the molecular mechanisms of cell adhesion and migration. By functionalizing surfaces with IKVAV, researchers can systematically analyze how cells interact with their microenvironment and respond to specific ECM-derived signals. This facilitates the identification of key adhesion molecules and signaling cascades, advancing our understanding of cell-matrix interactions in both normal and pathological contexts. The insights gained from these studies contribute to the rational design of bioactive materials and the development of novel strategies for modulating cellular behaviors.
Biomaterial Surface Modification: Surface modification of biomaterials with the IKVAV sequence enhances their performance in biological applications by imparting bioactivity and promoting selective cell interactions. The peptide can be covalently attached to a variety of substrates, including polymers, ceramics, and metals, to create functionalized surfaces that support cell attachment and growth. This approach is particularly valuable in the fabrication of implantable devices and tissue interfaces, where controlled cell adhesion and integration are paramount. By leveraging the bioactive properties of IKVAV, researchers are able to design advanced materials that meet the stringent requirements of next-generation biomedical devices and experimental platforms.
2. Cationic cell-penetrating peptides are potent furin inhibitors
5. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
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