J-2156 TFA is a peptide analog featuring aromatic and charged residues that modulate folding and ligand-recognition surfaces. Researchers apply it to study conformational equilibria, helix propensity, and solvent-driven structural transitions. The TFA salt improves solubility and purification consistency. Its architecture supports advanced mechanistic studies.
CAT No: R2202
CAS No:2387505-73-7
Synonyms/Alias:2387505-73-7;J-2156 TFA;J-2156 (TFA);(2S)-4-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanamide;2,2,2-trifluoroacetic acid;Unk-Dab-Phe-NH2.TFA;(S)-4-AMino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((4-methylnaphthalene)-1-sulfonamido)butanamide 2,2,2-trifluoroacetate;HY-111615A;MS-30439;CS-0120693;G17691;
J-2156 TFA is a synthetic peptide compound recognized for its selective agonist activity at the neuropeptide Y Y2 receptor. Structurally, it is a stable, engineered peptide analog designed to mimic endogenous neuropeptide Y fragments, offering potent receptor selectivity and bioactivity in experimental systems. Its unique sequence and receptor affinity make it a valuable molecular tool for dissecting the physiological roles of Y2 receptor-mediated signaling pathways. Researchers leverage its specificity to explore neuropeptide Y biology, making it a critical reagent for neuropharmacology, receptor characterization, and peptide signaling studies.
Receptor pharmacology: J-2156 TFA serves as a reference agonist in the study of neuropeptide Y Y2 receptor pharmacology. By selectively activating Y2 receptors, it enables researchers to delineate the downstream signaling cascades and physiological effects associated with this receptor subtype. Such studies are essential for mapping receptor-ligand interactions, characterizing receptor distribution, and understanding the functional consequences of Y2 receptor modulation in neural and peripheral tissues.
Signal transduction analysis: The compound is widely employed in cellular and molecular assays to investigate intracellular signaling events triggered by Y2 receptor activation. Its high selectivity allows for the isolation of Y2-mediated pathways, facilitating the measurement of second messenger responses, kinase activation, and gene expression changes in relevant cell models. These insights are critical for elucidating the mechanistic basis of neuropeptide Y signaling and its broader implications in neurobiology.
Peptide structure-activity relationship (SAR) studies: As a well-characterized synthetic peptide, J-2156 TFA is frequently used in SAR analyses to probe the structural determinants of Y2 receptor activation. By comparing its activity with that of analogs or modified fragments, researchers can identify key sequence motifs and conformational features necessary for high-affinity binding and receptor specificity. Such studies inform the rational design of novel peptide ligands with tailored pharmacological profiles.
In vitro assay development: The compound's stability and receptor selectivity make it a preferred standard in the development and validation of in vitro assays targeting the neuropeptide Y Y2 receptor. It is commonly used to calibrate bioassays, establish dose-response relationships, and benchmark the activity of novel agonists or antagonists. Reliable assay systems built around this peptide support high-throughput screening and facilitate drug discovery research focused on neuropeptide targets.
Neuropeptide Y system research: J-2156 TFA is integral to investigations exploring the physiological and biochemical roles of the neuropeptide Y system in various experimental settings. Its application extends to studies examining neurotransmission, synaptic plasticity, and neuroendocrine regulation, providing a tool to dissect the contributions of Y2 receptor signaling in complex biological processes. By enabling targeted modulation of this receptor subtype, the compound advances the understanding of neuropeptide Y's multifaceted functions in health and disease models.
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