J-2156 TFA is a peptide analog featuring aromatic and charged residues that modulate folding and ligand-recognition surfaces. Researchers apply it to study conformational equilibria, helix propensity, and solvent-driven structural transitions. The TFA salt improves solubility and purification consistency. Its architecture supports advanced mechanistic studies.
CAT No: R2202
CAS No:2387505-73-7
Synonyms/Alias:2387505-73-7;J-2156 TFA;J-2156 (TFA);(2S)-4-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanamide;2,2,2-trifluoroacetic acid;Unk-Dab-Phe-NH2.TFA;(S)-4-AMino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((4-methylnaphthalene)-1-sulfonamido)butanamide 2,2,2-trifluoroacetate;HY-111615A;MS-30439;CS-0120693;G17691;
J-2156 TFA is a synthetic carbohydrate compound recognized for its unique chemical structure and versatile reactivity, making it a valuable tool in advanced biochemical and molecular research. Characterized by its stability and solubility in aqueous solutions, J-2156 TFA is designed to facilitate a range of experimental applications that require precise molecular interactions. Its compatibility with various assay systems and ability to be incorporated into complex experimental workflows enable researchers to explore intricate biological pathways and mechanisms. The compound's robust profile supports both in vitro and in vivo studies, providing a reliable platform for scientists pursuing innovative research in glycobiology and related fields.
Pharmacological Research: In pharmacological investigations, J-2156 TFA serves as a critical probe for studying receptor-ligand interactions and signal transduction pathways. Researchers leverage its molecular specificity to dissect the roles of carbohydrate moieties in modulating cellular responses. By incorporating the compound into receptor binding assays and cell-based models, it becomes possible to elucidate the mechanistic underpinnings of various pharmacodynamic effects, thereby advancing the understanding of drug action at the molecular level.
Immunology Studies: Within the realm of immunology, J-2156 TFA is employed to investigate the modulation of immune cell activity and cytokine release. Its structural features enable selective engagement with glycan-binding proteins and immune receptors, providing insights into the regulation of immune responses. Scientists utilize this compound to explore the dynamics of immune signaling, including the activation and inhibition of key pathways involved in inflammation and cellular defense, thereby contributing to the identification of novel immunomodulatory targets.
Neuroscience Research: The application of J-2156 TFA in neuroscience is centered around its capacity to influence neural signaling and synaptic plasticity. By acting on specific carbohydrate-recognizing proteins within the nervous system, the compound aids in unraveling the molecular mechanisms underlying neuroprotection, neurotransmitter release, and neural network modulation. This research paves the way for a deeper understanding of neural function and the development of strategies to address neurodegenerative processes.
Cell Biology and Signal Transduction: In cell biology, J-2156 TFA is widely used to probe the intricacies of intracellular signaling cascades. Its integration into cellular assays allows for the detailed mapping of pathways influenced by carbohydrate-protein interactions, particularly those governing cell proliferation, differentiation, and apoptosis. The compound's ability to selectively modulate these pathways provides a foundation for exploring cellular homeostasis and the molecular basis of disease progression.
Glycobiology and Biochemical Pathway Analysis: The significance of J-2156 TFA extends to glycobiology, where it serves as a model compound for studying glycan-mediated processes. Researchers utilize it to characterize the enzymatic activities of glycosyltransferases and glycosidases, as well as to analyze the biosynthesis and remodeling of complex carbohydrates in biological systems. These investigations are crucial for deciphering the roles of glycans in cellular communication, protein folding, and metabolic regulation, offering valuable perspectives on the functional diversity of carbohydrate structures.
Chemical Biology Tool Development: As a versatile chemical tool, J-2156 TFA supports the creation of novel probes and molecular tags for advanced analytical techniques. Its distinct chemical properties facilitate the design of fluorescent or affinity-based conjugates, enabling high-resolution detection and quantification of carbohydrate interactions in complex biological matrices. This capability enhances the sensitivity and specificity of analytical workflows, empowering researchers to push the boundaries of molecular discovery and functional annotation. Through its multifaceted applications, J-2156 TFA continues to be an indispensable asset across diverse scientific disciplines, fostering progress in understanding the fundamental roles of carbohydrates in biological systems.
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