Larazotide acetate (also recognized as AT-1001) is a novel, synthetic, eight-amino acid peptide.
CAT No: 10-101-240
CAS No:881851-50-9/258818-34-7
Synonyms/Alias:Larazotide acetate;881851-50-9;AT-1001;Larazotide (acetate);UNII-FO8S2IW40N;Larazotide acetate [USAN];Larazotide acetate (USAN);FO8S2IW40N;acetic acid;2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]acetic acid;AT-1001 (LARAZOTIDE ACETATE);Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolylglycine acetate;Glycine, glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolyl-, monoacetate;AT1001;Larazotide Acetate?;Zot protein, Vibrio cholerae (288-293);CHEMBL2103815;NYGCNONRVCGHAT-UFIKZEAMSA-N;DTXSID401007986;LARAZOTIDE ACETATE [WHO-DD];AKOS040741936;CS-8047;HY-106268A;BS-44707;DA-74889;FL177565;D09352;F77451;Q25327025;Acetic acid--N-[(1-{N-[14-amino-1,4,7,10,13-pentahydroxy-5-(2-methylpropyl)-2,8-di(propan-2-yl)-3,6,9,12-tetraazatetradeca-3,6,9,12-tetraen-1-ylidene]-5-hydroxy-5-iminonorvalyl}pyrrolidin-2-yl)(hydroxy)methylidene]glycine (1/1);
Larazotide Acetate is a synthetic octapeptide that functions as a tight junction regulator, with significant relevance in studies of epithelial barrier integrity and paracellular permeability. As a peptide compound, it is structurally engineered to modulate the function of tight junctions within epithelial and endothelial cell layers, making it a valuable tool in investigations of mucosal barrier physiology. Its unique mechanism of action, which involves the modulation of zonulin signaling pathways, has positioned it at the forefront of research into gastrointestinal barrier dysfunction and related pathophysiological processes. Researchers utilize this peptide to interrogate the molecular underpinnings of barrier regulation, offering insights into the dynamic interactions that govern tissue homeostasis and immune surveillance.
Barrier Function Studies: Larazotide Acetate is widely employed in experimental models to assess and manipulate epithelial and endothelial barrier function. By modulating tight junction assembly and paracellular permeability, it enables precise investigation of the molecular determinants of barrier integrity. Studies utilizing this peptide help elucidate the signaling cascades and structural proteins involved in maintaining selective permeability, which is critical for understanding tissue compartmentalization and the prevention of unregulated solute flux.
Intestinal Permeability Assays: In gastrointestinal research, Larazotide Acetate serves as a powerful reagent for probing the mechanisms of intestinal permeability. Its ability to influence tight junction dynamics is exploited in both in vitro and ex vivo models to simulate and quantify barrier disruption and restoration. Researchers leverage its modulatory effects to characterize the impact of various stimuli—such as inflammatory cytokines, microbial products, or dietary components—on mucosal barrier function, thereby advancing the study of gut homeostasis and barrier-associated disorders.
Inflammation and Immune Response Research: The peptide's role as a tight junction regulator makes it particularly valuable in studies exploring the interplay between epithelial barriers and immune signaling. By altering paracellular flux, Larazotide Acetate facilitates the investigation of how compromised barriers contribute to antigen translocation and immune activation. This application is critical for dissecting the molecular crosstalk between epithelial cells and immune effectors, providing a deeper understanding of the initiation and propagation of inflammatory processes in barrier tissues.
Peptide Mechanism-of-Action Studies: Larazotide Acetate is frequently utilized to elucidate the biochemical and structural basis of peptide-mediated tight junction modulation. Its defined sequence and well-characterized activity provide a model system for examining peptide-receptor interactions, downstream signaling events, and the conformational changes in tight junction complexes. These studies not only advance the fundamental understanding of peptide function but also inform the rational design of novel tight junction modulators for research purposes.
Analytical and Screening Applications: The compound is incorporated into high-throughput screening assays and analytical platforms aimed at identifying modulators of epithelial barrier function. Its predictable activity profile makes it a reliable positive control or reference standard in assays evaluating the efficacy of candidate molecules intended to strengthen or disrupt tight junctions. Such applications are instrumental in the preclinical evaluation of barrier-targeting agents and in the development of new research tools for studying tissue permeability and homeostasis.
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