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Larazotide Acetate

Larazotide acetate (also recognized as AT-1001) is a novel, synthetic, eight-amino acid peptide.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-240

CAS No:881851-50-9/258818-34-7

Synonyms/Alias:Larazotide acetate;881851-50-9;AT-1001;Larazotide (acetate);UNII-FO8S2IW40N;Larazotide acetate [USAN];Larazotide acetate (USAN);FO8S2IW40N;acetic acid;2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]acetic acid;AT-1001 (LARAZOTIDE ACETATE);Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolylglycine acetate;Glycine, glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolyl-, monoacetate;AT1001;Larazotide Acetate?;Zot protein, Vibrio cholerae (288-293);CHEMBL2103815;NYGCNONRVCGHAT-UFIKZEAMSA-N;DTXSID401007986;LARAZOTIDE ACETATE [WHO-DD];AKOS040741936;CS-8047;HY-106268A;BS-44707;DA-74889;FL177565;D09352;F77451;Q25327025;Acetic acid--N-[(1-{N-[14-amino-1,4,7,10,13-pentahydroxy-5-(2-methylpropyl)-2,8-di(propan-2-yl)-3,6,9,12-tetraazatetradeca-3,6,9,12-tetraen-1-ylidene]-5-hydroxy-5-iminonorvalyl}pyrrolidin-2-yl)(hydroxy)methylidene]glycine (1/1);

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C34H59N9O12
M.W/Mr.
785.9
Sequence
One Letter Code:GGVLVQPG
Three Letter Code:H-Gly-Gly-Val-Leu-Val-Gln-Pro-Gly-OH.CH3CO2H
Appearance
White Solid
Biological Activity
AT-1001, also known as Larazotide Acetate, is a tight junction regulator and reverses leaky junctions to their normally closed state. It is being studied in people with celiac disease.
Long-term Storage Conditions
Water (Slightly)
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C32H55N9O10.C2H4O2/c1-16(2)12-20(38-30(49)26(17(3)4)39-24(44)14-35-23(43)13-33)28(47)40-27(18(5)6)31(50)37-19(9-10-22(34)42)32(51)41-11-7-8-21(41)29(48)36-15-25(45)46;1-2(3)4/h16-21,26-27H,7-15,33H2,1-6H3,(H2,34,42)(H,35,43)(H,36,48)(H,37,50)(H,38,49)(H,39,44)(H,40,47)(H,45,46);1H3,(H,3,4)/t19-,20-,21-,26-,27-;/m0./s1
InChI Key
NYGCNONRVCGHAT-UFIKZEAMSA-N

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