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LCMV GP (61-80)

LCMV infection has been shown to induce a relatively strong T-helper response (at least in C57BL/6 mice) focused almost entirely upon two epitopes, GP61–80 and NP309–328, both of which are presented by I-Ab. The LCMV 61-80 peptide acts preferentially as an LCMV T helper epitope and this epitope seems to be processed differently (lysosomal-independent pathway) for viral cell-mediated targeting.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: V14005

Synonyms/Alias:LCMV GP (61-80);232598-19-5;AKOS040757558;DA-54828;

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C108H160N24O31
M.W/Mr.
2290.6
Sequence
One Letter Code:GLKGPDIYKGVYQFKSVEFD
Three Letter Code:H-Gly-Leu-Lys-Gly-Pro-Asp-Ile-Tyr-Lys-Gly-Val-Tyr-Gln-Phe-Lys-Ser-Val-Glu-Phe-Asp-OH
InChI
InChI=1S/C108H160N24O31/c1-9-61(8)91(131-102(156)78(52-87(142)143)124-104(158)81-30-22-46-132(81)85(139)56-115-93(147)69(28-17-20-44-110)117-97(151)73(47-58(2)3)116-83(137)54-112)107(161)126-77(51-65-33-37-67(135)38-34-65)99(153)118-68(27-16-19-43-109)92(146)114-55-84(138)129-89(59(4)5)105(159)125-76(50-64-31-35-66(134)36-32-64)100(154)120-71(39-41-82(113)136)95(149)122-74(48-62-23-12-10-13-24-62)98(152)119-70(29-18-21-45-111)94(148)128-80(57-133)103(157)130-90(60(6)7)106(160)121-72(40-42-86(140)141)96(150)123-75(49-63-25-14-11-15-26-63)101(155)127-79(108(162)163)53-88(144)145/h10-15,23-26,31-38,58-61,68-81,89-91,133-135H,9,16-22,27-30,39-57,109-112H2,1-8H3,(H2,113,136)(H,114,146)(H,115,147)(H,116,137)(H,117,151)(H,118,153)(H,119,152)(H,120,154)(H,121,160)(H,122,149)(H,123,150)(H,124,158)(H,125,159)(H,126,161)(H,127,155)(H,128,148)(H,129,138)(H,130,157)(H,131,156)(H,140,141)(H,142,143)(H,144,145)(H,162,163)/t61-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,89-,90-,91-/m0/s1
InChI Key
FZOSFZDRHOCVOK-TVDVXXQISA-N
References
Rodriguez, F. et al. J Virol 75, 10421 (2001).

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