Lys-γ3-MSH integrates a functional melanocortin-derived motif that helps explore receptor-interaction patterns. Its hydrophobic and charged residues contribute to structured conformational states. Researchers analyze solvent effects, binding equilibria, and motif-driven folding. Use cases span peptide ligand design, structural mimicry, and receptor-binding studies.
CAT No: R2613
CAS No:156159-18-1
Synonyms/Alias:Lys-gamma3-MSH;156159-18-1;AKOS024457716;PD079568;
Lys-gamma3-MSH is a synthetic peptide analogue derived from the melanocyte-stimulating hormone (MSH) family, characterized by the presence of a lysine residue and a modified gamma3 sequence. As a bioactive peptide, it is of significant interest in biochemical and pharmacological research due to its ability to interact with melanocortin receptors. Its unique sequence enables targeted studies of receptor selectivity and downstream signaling pathways, making it a valuable tool for researchers investigating peptide-receptor interactions, melanocortin system modulation, and the broader field of peptide-based signaling mechanisms.
Receptor Binding Studies: Lys-gamma3-MSH is widely utilized in receptor binding assays to elucidate the specificity and affinity of melanocortin receptor subtypes, particularly MC1R, MC3R, MC4R, and MC5R. By serving as a selective ligand, it enables detailed mapping of binding domains and the assessment of structure-activity relationships within the melanocortin receptor family. This application supports the identification of critical amino acid residues involved in ligand recognition and receptor activation, providing foundational insights for the development of novel modulators.
Signal Transduction Research: The peptide is instrumental in dissecting intracellular signaling cascades initiated by melanocortin receptor activation. Researchers employ Lys-gamma3-MSH in cell-based assays to monitor downstream events such as cAMP accumulation, phosphorylation of signaling proteins, and gene expression changes. These studies contribute to a deeper understanding of how structural modifications in peptide ligands influence receptor-mediated signaling, which is essential for advancing knowledge of GPCR function and regulation.
Peptide Structure-Function Analysis: The modified sequence of Lys-gamma3-MSH allows for systematic investigations into how specific amino acid substitutions affect peptide conformation, stability, and bioactivity. By comparing its functional properties to those of native and other synthetic MSH analogues, scientists can delineate the molecular determinants of selectivity and potency. Such analyses are crucial for rational peptide design and the optimization of bioactive peptides for research and industrial applications.
Development of Analytical Methods: Owing to its defined structure and functional relevance, Lys-gamma3-MSH serves as a standard or reference compound in the development and validation of analytical techniques, including high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassays. Its use in method development ensures accurate quantification and characterization of peptide samples, supporting quality control processes and the advancement of peptide analytics in research laboratories.
Peptide-Based Screening Platforms: In high-throughput screening and assay development, Lys-gamma3-MSH is employed as a model peptide to evaluate the performance of detection systems, binding assays, and biosensors targeting melanocortin-related pathways. Its application in these platforms facilitates the identification of novel ligands, inhibitors, or modulators, thereby accelerating discovery efforts in peptide therapeutics, diagnostics, and receptor biology. The versatility and well-characterized nature of this peptide make it a preferred choice in the establishment of robust screening methodologies.
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