Lysipressin Acetate is an analog of Vasopressin, a powerful vasopressor used to modulate blood pressure. An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action.
CAT No: R1955
CAS No:83968-49-4
Synonyms/Alias:Lysipressin acetate;83968-49-4;Lysipressinacetate;Vasopressin, 8-l-lysine-, monoacetate (salt);Lysipressin (acetate);EINECS 281-529-6;Lysipressin Acetic Acid Salt;acetic acid;(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;NKWAIKZITYLOMT-DHSVNZEYSA-N;AKOS030485978;CS-0012393;C76681;
Chemical Name:acetic acid;(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Lysipressin acetate is a synthetic peptide analog of the naturally occurring antidiuretic hormone vasopressin, distinguished by its unique lysine residue at the eighth position. As a member of the neurohypophyseal hormone family, it exhibits potent vasopressin-like activity, particularly in modulating water balance and vascular tone. Its biochemical profile and receptor selectivity make it a valuable research tool for dissecting the physiological and pharmacological roles of vasopressin analogs. Owing to its stability and defined sequence, lysipressin acetate is widely utilized in experimental systems to probe peptide-receptor interactions, signal transduction pathways, and the functional consequences of neuroendocrine regulation.
Receptor binding studies: Lysipressin acetate serves as a highly specific ligand in receptor binding assays aimed at characterizing vasopressin receptor subtypes, especially V2 receptors. Its structural similarity to endogenous vasopressin, coupled with the lysine substitution, enables researchers to investigate binding affinities, receptor activation profiles, and downstream signaling events. Such studies are instrumental for elucidating the molecular determinants of receptor selectivity and for screening novel modulators of the vasopressinergic system.
Signal transduction research: The peptide is frequently employed in cellular models to stimulate and analyze intracellular signaling cascades triggered by vasopressin receptor activation. By applying lysipressin acetate to cultured cells or tissue preparations, investigators can monitor second messenger production, such as cAMP or calcium mobilization, and assess the functional coupling of G protein-coupled receptors. These experiments contribute to a deeper understanding of hormone-mediated signaling and the regulatory mechanisms governing cell physiology.
Peptide structure-activity relationship analysis: Lysipressin acetate is an essential reference compound in structure-activity relationship (SAR) studies within the field of peptide chemistry. By comparing its biological activity and receptor interactions with those of other vasopressin analogs, researchers can delineate the impact of specific amino acid substitutions on peptide function. This knowledge underpins the rational design of novel analogs with tailored pharmacological profiles for research and industrial applications.
Water transport and osmoregulation investigations: Because of its robust antidiuretic properties, lysipressin acetate is a preferred experimental agent for probing mechanisms of renal water reabsorption and systemic osmoregulation. In ex vivo and in vitro systems, it is used to stimulate water channel insertion and assess the regulatory dynamics of aquaporin trafficking. These applications are fundamental for advancing knowledge of fluid homeostasis and the hormonal control of kidney function.
Peptide assay development: The well-characterized sequence and bioactivity of lysipressin acetate make it an ideal standard or control in the development and validation of analytical assays for peptide hormones. It is commonly utilized in chromatographic, immunoassay, or mass spectrometric platforms to optimize detection parameters, calibrate quantification methods, and ensure assay reliability. Such roles are critical for supporting peptide research, quality control, and biotechnological innovation.
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