Mas7, a structural analogue of mastoparan, is an activator of heterotrimeric Gi proteins and its downstream effectors.
CAT No: R1506
CAS No:145854-59-7
Synonyms/Alias:Mastoparan 7;145854-59-7;Mas7;Mas 7;Mastoparan-7;L-Leucinamide, L-isoleucyl-L-asparaginyl-L-leucyl-L-lysyl-L-alanyl-L-leucyl-L-alanyl-L-alanyl-L-leucyl-L-alanyl-L-lysyl-L-alanyl-L-leucyl-;DTXSID70163171;Mastoparan 7 acetate;Mast cell degranulating peptide (Vespula lewisii), 12-L-alanine-13-L-leucine-;MFCD00144726;DTXCID0085662;SCHEMBL16197312;FM73480;G90946;Mastoparan-7, >=97% (HPLC), lyophilized powder;
Mas7, also known as Mas-related G-protein coupled receptor agonist 7, is a synthetic amphiphilic peptide widely utilized in biochemical and cellular research. As a member of the mastoparan family, it is structurally derived from wasp venom peptides and is characterized by its ability to modulate intracellular signaling pathways, particularly those involving G-protein coupled receptors (GPCRs). Mas7 is notable for its capacity to permeabilize cell membranes and stimulate G-protein activity, making it a valuable tool for dissecting complex signal transduction processes. Its unique biochemical properties have established it as an essential reagent in studies focused on receptor pharmacology, cell signaling dynamics, and membrane biology.
GPCR signaling research: Mas7 serves as a potent activator of heterotrimeric G-proteins, particularly the Gi and Go subtypes, independent of receptor ligation. By mimicking the natural activation process, it enables researchers to directly probe downstream signaling cascades, such as those involving second messengers like cAMP and intracellular calcium. This capacity is instrumental in elucidating the molecular mechanisms governing GPCR-mediated pathways, supporting the development of new pharmacological tools and enhancing the understanding of receptor-effector coupling in diverse cell types.
Membrane permeabilization studies: The amphiphilic nature of this peptide allows it to interact intimately with phospholipid bilayers, facilitating transient membrane permeabilization. Researchers employ Mas7 to selectively alter membrane integrity, thereby enabling the controlled delivery of small molecules, ions, or labeling reagents into the cytosol of living cells. This property is particularly valuable for experimental protocols that require precise manipulation of intracellular environments without compromising overall cell viability.
Neurotransmitter release assays: In neurobiology, Mas7 is frequently used to trigger neurotransmitter exocytosis from synaptosomes and cultured neurons. By directly activating G-proteins associated with synaptic vesicle fusion machinery, it provides a robust model for investigating the regulatory mechanisms underlying synaptic transmission. Such studies contribute to a deeper understanding of neuronal communication, synaptic plasticity, and the modulation of neural networks.
Signal transduction pathway mapping: The peptide's ability to activate G-proteins in a receptor-independent manner makes it a powerful tool for dissecting downstream signaling networks. Researchers utilize it to differentiate between receptor-mediated and direct G-protein-mediated effects, allowing for the mapping of specific branches within complex signaling pathways. This approach facilitates the identification of novel molecular targets and the characterization of effector proteins involved in cellular responses.
Pharmacological screening and assay development: Mas7 is commonly incorporated into high-throughput screening assays designed to evaluate the functional status of G-protein signaling components. Its well-characterized mechanism of action provides a reliable positive control for validating assay sensitivity and specificity. By enabling the assessment of compound libraries or genetic perturbations on G-protein activity, it supports the discovery of new modulators of intracellular signaling and enhances the robustness of screening platforms in drug discovery research.
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
2. Cationic cell-penetrating peptides are potent furin inhibitors
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