MC-Gly-Gly-Phe-Gly

    MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

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    MC-Gly-Gly-Phe-Gly(CAS 2413428-36-9)

    CAT No: R1896

    CAS No: 2413428-36-9

    Chemical Name: (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)glycylglycyl-L-phenylalanylglycine

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    cGMP Peptide

    Registration of APIs CMC information required for an IND

    IND and NDA support Drug master files (DMF) filing

    Specification Technical Data Publications Customer reviews and Q&A
    Synonyms/AliasMC-Gly-Gly-Phe-Gly;2413428-36-9;Mc-GGFG-OH;(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)glycylglycyl-L-phenylalanylglycine;(S)-5-Benzyl-18-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecan-1-oic acid;2-[[(2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid;[(2S)-2-(2-{2-[6-(2,5-dioxopyrrol-1-yl)hexanamido]acetamido}acetamido)-3-phenylpropanamido]acetic acid;MC-Gly-Gly-Phe-Gly?;SCHEMBL23630027;EX-A4372;AKOS040759486;BP-28746;HY-44246;MS-29798;PD171746;CS-0106632;F78341;
    M.F/FormulaC25H31N5O8
    M.W/Mr.529.5
    SequenceOne Letter Code:GGFG
    AppearanceSolid powder
    Long-term Storage ConditionsSoluble in DMSO
    Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
    InChIInChI=1S/C25H31N5O8/c31-19(9-5-2-6-12-30-22(34)10-11-23(30)35)26-14-20(32)27-15-21(33)29-18(25(38)28-16-24(36)37)13-17-7-3-1-4-8-17/h1,3-4,7-8,10-11,18H,2,5-6,9,12-16H2,(H,26,31)(H,27,32)(H,28,38)(H,29,33)(H,36,37)/t18-/m0/s1
    InChI KeyDWPLKZYCOGLRPC-SFHVURJKSA-N
    Canonical SMILESO=C(CCCCCN1C(C=CC1=O)=O)NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)=O)=O

    1. Multifunctional peptide-oligonucleotide conjugate promoted sensitive electrochemical biosensing of cardiac troponin I

    2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

    3. Implications of ligand-receptor binding kinetics on GLP-1R signalling

    4. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

    5. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

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