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MC-Gly-Gly-Phe-Gly

MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
MC-Gly-Gly-Phe-Gly(CAS 2413428-36-9)

CAT No: R1896

CAS No:2413428-36-9

Synonyms/Alias:MC-Gly-Gly-Phe-Gly;2413428-36-9;Mc-GGFG-OH;(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)glycylglycyl-L-phenylalanylglycine;(S)-5-Benzyl-18-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecan-1-oic acid;2-[[(2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid;[(2S)-2-(2-{2-[6-(2,5-dioxopyrrol-1-yl)hexanamido]acetamido}acetamido)-3-phenylpropanamido]acetic acid;MC-Gly-Gly-Phe-Gly?;SCHEMBL23630027;EX-A4372;AKOS040759486;BP-28746;HY-44246;MS-29798;PD171746;CS-0106632;F78341;

Chemical Name:(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)glycylglycyl-L-phenylalanylglycine

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C25H31N5O8
M.W/Mr.
529.5
Sequence
One Letter Code:GGFG
Appearance
Solid powder
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
InChI
InChI=1S/C25H31N5O8/c31-19(9-5-2-6-12-30-22(34)10-11-23(30)35)26-14-20(32)27-15-21(33)29-18(25(38)28-16-24(36)37)13-17-7-3-1-4-8-17/h1,3-4,7-8,10-11,18H,2,5-6,9,12-16H2,(H,26,31)(H,27,32)(H,28,38)(H,29,33)(H,36,37)/t18-/m0/s1
InChI Key
DWPLKZYCOGLRPC-SFHVURJKSA-N
Canonical SMILES
O=C(CCCCCN1C(C=CC1=O)=O)NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)=O)=O

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