MCL 0020 is an effective and selective antagonist of peptidemimetic melanocortin MC4 receptor (IC50 =11.63 nM), exhibits anxiolytic-like activity in vivo.
CAT No: R0999
CAS No:475498-26-1
Synonyms/Alias:MCL 0020;475498-26-1;475498-27-2;Ac-D-2Nal-Arg-D-2Nal-NH2;SCHEMBL6552897;DTXSID801133238;AUA49826;AKOS024457630;DA-65294;TS-10499;D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-;(2S)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-N-[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide;(2S)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-N-[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-5-carbamimidamidopentanamide; MCL 0020;(2S)-5-carbamimidamido-N-[(1R)-1-carbamoyl-2-(naphthalen-2-yl)ethyl]-2-[(2R)-2-acetamido-3-(naphthalen-2-yl)propanamido]pentanamide;(S)-2-((R)-2-Acetamido-3-(naphthalen-2-yl)propanamido)-N-((R)-1-amino-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide;
MCL 0020 is a synthetic peptide compound designed for advanced biochemical research and development applications. As a structurally defined peptide, it offers precise sequence control and functional versatility, making it a valuable tool in the study of protein-protein interactions, receptor signaling, and molecular recognition processes. Its engineered characteristics facilitate targeted investigations into cellular mechanisms, providing researchers with a reliable platform for probing complex biological systems. The compound's stability and compatibility with a range of experimental conditions further enhance its utility in both academic and industrial laboratory settings, where reproducibility and specificity are paramount.
Peptide-based assay development: MCL 0020 is frequently utilized in the design and optimization of peptide-based assays, particularly those aimed at quantifying or detecting specific biomolecular interactions. Its defined sequence allows for selective binding studies, enabling researchers to dissect the affinities and kinetics of receptor-ligand or enzyme-substrate interactions. This capability is essential for the development of high-throughput screening platforms and diagnostic tools that rely on robust, reproducible peptide interactions.
Signal transduction research: The compound serves as a model peptide for elucidating intracellular signaling pathways. Researchers employ it to mimic natural motifs or domains involved in cellular communication, thereby enabling the mapping of downstream effectors and the identification of regulatory checkpoints. By integrating MCL 0020 into cellular or cell-free systems, investigators can systematically analyze how specific peptide sequences modulate kinase activity, phosphorylation events, or adaptor protein recruitment, providing insights into the dynamic regulation of signal transduction networks.
Structure-activity relationship (SAR) studies: MCL 0020 is instrumental in structure-activity relationship investigations, where subtle modifications to its sequence or conformation yield critical data on the determinants of biological activity. By systematically altering side chains or backbone structures, researchers can pinpoint key residues responsible for binding affinity, specificity, or functional efficacy. These SAR studies inform the rational design of next-generation peptides with enhanced properties for research or industrial use.
Peptide synthesis and method validation: The compound is also employed as a reference standard or test substrate in the validation of peptide synthesis methodologies. Its well-characterized sequence and predictable behavior make it suitable for benchmarking solid-phase peptide synthesis protocols, purification strategies, and analytical techniques such as mass spectrometry or HPLC. Using MCL 0020 in method development ensures accuracy and consistency in peptide production workflows, supporting quality control initiatives across research and manufacturing environments.
Protein engineering and functional studies: In protein engineering contexts, MCL 0020 acts as a modular unit for constructing chimeric proteins, fusion constructs, or peptide-tagged biomolecules. Its incorporation enables targeted functionalization, localization, or detection of recombinant proteins in complex biological samples. Researchers leverage its sequence-specific properties to facilitate purification, imaging, or activity assays, advancing the study of protein function, interaction networks, and cellular localization with high precision and reproducibility.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More