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MCL 0020

MCL 0020 is an effective and selective antagonist of peptidemimetic melanocortin MC4 receptor (IC50 =11.63 nM), exhibits anxiolytic-like activity in vivo.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
MCL 0020(CAS 475498-26-1)

CAT No: R0999

CAS No:475498-26-1

Synonyms/Alias:MCL 0020;475498-26-1;475498-27-2;Ac-D-2Nal-Arg-D-2Nal-NH2;SCHEMBL6552897;DTXSID801133238;AUA49826;AKOS024457630;DA-65294;TS-10499;D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-;(2S)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-N-[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide;(2S)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-N-[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-5-carbamimidamidopentanamide; MCL 0020;(2S)-5-carbamimidamido-N-[(1R)-1-carbamoyl-2-(naphthalen-2-yl)ethyl]-2-[(2R)-2-acetamido-3-(naphthalen-2-yl)propanamido]pentanamide;(S)-2-((R)-2-Acetamido-3-(naphthalen-2-yl)propanamido)-N-((R)-1-amino-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C34H39N7O4
M.W/Mr.
609.7
Sequence
One Letter Code:XRX
Three Letter Code:Ac-D-2Nal-Arg-D-2Nal-NH2
Appearance
White lyophilised solid
Purity
>98 %
Activity
Antagonist
Shipping Condition
Wet ice in continental US; may vary elsewhere
InChI
InChI=1S/C34H39N7O4/c1-21(42)39-30(20-23-13-15-25-8-3-5-10-27(25)18-23)33(45)40-28(11-6-16-38-34(36)37)32(44)41-29(31(35)43)19-22-12-14-24-7-2-4-9-26(24)17-22/h2-5,7-10,12-15,17-18,28-30H,6,11,16,19-20H2,1H3,(H2,35,43)(H,39,42)(H,40,45)(H,41,44)(H4,36,37,38)/t28-,29+,30+/m0/s1
InChI Key
FJFLYSMWSRRMRO-FRXPANAUSA-N
Isomeric SMILES
CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CC4=CC=CC=C4C=C3)C(=O)N

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