Mif-1 (TFA) is a short tripeptide containing aromatic and hydrophobic residues arranged to favor compact structural motifs. The TFA form offers enhanced solubility and purification consistency. Researchers use it to explore residue-specific interactions, folding tendencies, and enzymatic behavior. Its small size supports high-sensitivity structural analysis.
CAT No: R2213
CAS No:35240-69-8
Synonyms/Alias:MIF-1 (TFA);MIF-1 TFA;35240-69-8;(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid;HY-107663A;MS-26730;CS-0136863;G17455;EN300-27126451;L-prolyl-L-leucyl-glycinamide,trifluoroacetatesalt;(2S)-N-(carbamoylmethyl)-4-methyl-2-{[(2S)-pyrrolidin-2-yl]formamido}pentanamide; trifluoroacetic acid;
Mif-1 (tfa), also known as Melanocyte-Inhibiting Factor 1 trifluoroacetate salt, is a synthetic tripeptide derivative that has garnered significant attention in the field of neuropeptide research. Characterized by its unique sequence and stability, this compound is valued for its ability to modulate neurochemical pathways and influence various physiological processes. As a research tool, Mif-1 (tfa) offers versatility in experimental settings, allowing scientists to explore its diverse biological roles and interactions. Its solubility and compatibility with various assay systems further enhance its utility in both in vitro and in vivo studies, making it a preferred choice for laboratories investigating peptide function and signaling.
Neuropharmacology research: Mif-1 (tfa) is extensively utilized in neuropharmacological studies to investigate the mechanisms underlying neurotransmitter regulation and neuromodulation. Researchers employ this peptide to examine its effects on the central nervous system, particularly its interaction with endogenous opioid systems and monoaminergic pathways. By modulating these pathways, the compound serves as a valuable tool for elucidating the molecular basis of mood regulation, stress response, and reward processing. Its application in receptor binding assays and behavioral models helps delineate the specific roles of neuropeptides in brain function and supports the development of novel hypotheses regarding neurochemical balance.
Peptide receptor studies: The tripeptide is frequently used in receptor binding and signaling studies to characterize its affinity and selectivity for specific peptide receptors. Scientists leverage its structural properties to map binding sites, assess receptor activation, and monitor downstream signaling cascades. Through these investigations, Mif-1 (tfa) contributes to a deeper understanding of peptide-receptor interactions, informing the design of receptor-targeted ligands and the identification of novel therapeutic targets. Its use in competitive binding assays and cell-based functional assays provides critical insights into the specificity and efficacy of neuropeptide signaling.
Behavioral neuroscience: In the realm of behavioral neuroscience, Melanocyte-Inhibiting Factor 1 trifluoroacetate is employed to explore its influence on animal behavior and cognitive processes. Researchers utilize the compound in preclinical models to study its effects on learning, memory, anxiety-like behaviors, and social interactions. By administering the peptide in controlled experiments, scientists can observe alterations in behavioral outcomes, thereby linking neurochemical modulation to observable phenotypes. These studies are instrumental in uncovering the complex interplay between neuropeptides and behavior, advancing our knowledge of brain-behavior relationships.
Peptide stability and formulation research: The stability and formulation properties of Mif-1 (tfa) are of particular interest to researchers developing peptide-based delivery systems. Its trifluoroacetate salt form offers enhanced solubility and stability, making it an ideal candidate for studies focused on optimizing peptide formulations for experimental use. Scientists investigate its compatibility with various solvents, excipients, and delivery vehicles to ensure reproducibility and reliability in peptide administration. These formulation studies are essential for maintaining the integrity of the compound during storage and experimental procedures, thereby supporting robust and consistent research outcomes.
Structure-activity relationship (SAR) analysis: Structure-activity relationship studies benefit from the use of Mif-1 (tfa) as a reference compound for comparing the effects of structural modifications on biological activity. By synthesizing analogs and assessing their functional properties relative to the parent peptide, researchers can identify key structural determinants of activity and selectivity. This approach facilitates rational peptide design and the development of novel neuropeptide analogs with enhanced potency or specificity. SAR analysis supported by Mif-1 (tfa) thus contributes to the broader field of peptide chemistry and neurobiology, enabling the advancement of targeted molecular tools for research applications.
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