Mif-1 (TFA) is a short tripeptide containing aromatic and hydrophobic residues arranged to favor compact structural motifs. The TFA form offers enhanced solubility and purification consistency. Researchers use it to explore residue-specific interactions, folding tendencies, and enzymatic behavior. Its small size supports high-sensitivity structural analysis.
CAT No: R2213
CAS No:35240-69-8
Synonyms/Alias:MIF-1 (TFA);MIF-1 TFA;35240-69-8;(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid;HY-107663A;MS-26730;CS-0136863;G17455;EN300-27126451;L-prolyl-L-leucyl-glycinamide,trifluoroacetatesalt;(2S)-N-(carbamoylmethyl)-4-methyl-2-{[(2S)-pyrrolidin-2-yl]formamido}pentanamide; trifluoroacetic acid;
Mif-1 (tfa), also known as Melanocyte-Inhibiting Factor-1 trifluoroacetate salt, is a synthetic tripeptide with the sequence Pro-Leu-Gly-NH2. As a peptide compound, it is recognized for its modulatory effects on neuropeptide signaling and its influence on central nervous system biochemistry. Researchers value Mif-1 for its unique ability to interact with various neuroreceptors and peptide-regulated pathways, making it a significant tool in neurobiological, pharmacological, and behavioral studies. Its structural simplicity, combined with its distinct bioactivity profile, has established its relevance in investigations related to peptide function, neurotransmission, and the molecular mechanisms governing neuropeptide activity.
Neuropharmacology research: Mif-1 (tfa) is widely employed in neuropharmacological studies to elucidate the mechanisms of neuropeptide signaling and receptor modulation. By serving as a model tripeptide, it enables researchers to investigate the interaction of small peptides with receptors such as dopamine and opioid receptors, providing insight into the regulatory roles of endogenous peptides in neural circuits. The compound's ability to modulate neurotransmitter systems makes it a valuable tool for dissecting the molecular underpinnings of neurochemical communication and synaptic plasticity.
Peptide-receptor interaction studies: As a well-characterized peptide ligand, Mif-1 is instrumental in experiments designed to map the binding affinities and selectivity of peptide-receptor interactions. Its established activity profile facilitates the exploration of structure-activity relationships, helping to identify critical sequence motifs necessary for receptor engagement. Such studies are essential for advancing the understanding of peptide-based signaling networks and for informing the rational design of novel peptide analogs with tailored receptor specificity.
Behavioral neuroscience: The use of Mif-1 in behavioral assays allows for the assessment of neuropeptide contributions to complex behaviors and cognitive processes. Researchers utilize this tripeptide to probe the functional consequences of peptide modulation in animal models, examining outcomes such as learning, memory, and stress response. These investigations contribute to the broader understanding of how peptide signaling influences behavioral phenotypes and neuroadaptive responses.
Peptide synthesis and analytical method development: Mif-1 serves as a reference standard and benchmarking compound in peptide synthesis protocols and analytical method validation. Its defined sequence and well-documented properties make it suitable for calibrating chromatographic systems, optimizing purification strategies, and evaluating peptide quantification techniques. This role is particularly important for laboratories developing robust methods for peptide production and quality assessment.
Neuropeptide degradation and metabolic pathway analysis: The compound is also utilized to study the enzymatic degradation and metabolic fate of small peptides in biological systems. By tracking the breakdown products and assessing the activity of peptidases, researchers can gain detailed insights into the stability, turnover, and inactivation pathways of neuropeptides. Such analyses inform the broader field of peptide metabolism and support the development of strategies to modulate peptide half-life and bioavailability in experimental systems.
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