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MLCK inhibitor peptide 18

MLCK inhibitor peptide 18 is a cell-permeable inhibitor of myosin light chain kinase (MLCK; IC50 = 50 nM), and displays 4000-fold selectivity over cam kinase ii and does not inhibit PKA. It prevents defects in transepithelial barrier resistance induced by bacteria or TNF-α plus IFN-γ. MLCK inhibitor peptide 18 prevents sperm chromatin-induced cortical reorganization in mouse oocytes and decreases phagocytosis of C3bi-opsonized and non-opsonized myelin by primary mouse microglia.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
MLCK inhibitor peptide 18(CAS 224579-74-2)

CAT No: R0854

CAS No:224579-74-2

Synonyms/Alias:MLCK inhibitor peptide 18;224579-74-2;Myosin Light Chain Kinase Inhibitor Peptide 18;CHEMBL443574;peptide 18;H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2;MLCK Inhibitor Peptide-18;GTPL9351;GLXC-15538;ZIA57974;R-K-K-Y-K-Y-R-R-K-NH2;BDBM50074638;AKOS024456829;DA-65540;G13301;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C60H105N23O11
M.W/Mr.
1324.6
Sequence
One Letter Code:RKKYKYRRK
Three Letter Code:H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2
Labeling Target
Myosin
Appearance
Crystalline solid
Purity
≥95%
Activity
Inhibitor
Areas of Interest
Immunology & Inflammation
Cell Biology
Solubility
-20 °C
InChI
InChI=1S/C60H105N23O11/c61-27-5-1-13-41(49(66)86)76-51(88)45(17-10-32-74-59(69)70)79-53(90)46(18-11-33-75-60(71)72)81-57(94)48(35-37-21-25-39(85)26-22-37)83-55(92)44(16-4-8-30-64)80-56(93)47(34-36-19-23-38(84)24-20-36)82-54(91)43(15-3-7-29-63)78-52(89)42(14-2-6-28-62)77-50(87)40(65)12-9-31-73-58(67)68/h19-26,40-48,84-85H,1-18,27-35,61-65H2,(H2,66,86)(H,76,88)(H,77,87)(H,78,89)(H,79,90)(H,80,93)(H,81,94)(H,82,91)(H,83,92)(H4,67,68,73)(H4,69,70,74)(H4,71,72,75)/t40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1
InChI Key
JPOKAKNGULMYHZ-UILVTTEASA-N
Isomeric SMILES
C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N)O

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