Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
CAT No: R1525
CAS No:110570-93-9
Synonyms/Alias:myomodulin;110570-93-9;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]pyrrolidine-2-carboxamide;Myomoduline A (Aplysia californica);Myomodulin A;Myomodulin A trifluoroacetate salt;HY-P0268;Myomodulin a(aplysiacalifornica)(9ci);AKOS040764116;DA-65729;(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-4-(methylsulfanyl)-2-[(2S)-pyrrolidin-2-ylformamido]butanamido]propanamido]-4-(methylsulfanyl)butanamido]-4-methylpentanamido]pentanamido]-4-methylpentanamide;
Myomodulin is a neuropeptide that plays a significant modulatory role in invertebrate nervous systems, particularly within molluscan and insect models. As a member of the FMRFamide-related peptide family, it is characterized by a conserved amidated C-terminus and a variable N-terminal sequence, which confers specificity in receptor interactions and physiological effects. Myomodulin is primarily recognized for its involvement in neuromodulation, synaptic plasticity, and the regulation of muscle contraction, making it a valuable tool for dissecting peptide signaling pathways. Its well-documented activity in modulating neuronal excitability and influencing rhythmic motor patterns underscores its importance in neurobiological and physiological research.
Neurophysiology research: Myomodulin serves as a critical probe for investigating the mechanisms of neuromodulation within invertebrate model systems. By applying synthetic myomodulin to isolated ganglia or neuronal networks, researchers can systematically assess its effects on synaptic transmission, membrane potential, and action potential firing. These experiments provide insights into how neuropeptides fine-tune neuronal activity, facilitate synaptic integration, and contribute to the generation and modulation of complex motor patterns. Such studies are instrumental in elucidating the broader principles of neuropeptide function and signaling dynamics.
Muscle physiology studies: The peptide is commonly used in experimental paradigms to explore the regulation of muscle contractility and excitability. Myomodulin has been shown to modulate the activity of ion channels and second messenger systems in muscle cells, leading to alterations in contraction strength and rhythmicity. By incorporating it into in vitro muscle assays, scientists can dissect the molecular and cellular underpinnings of neuromuscular communication, understand how peptide hormones influence muscle tone, and model the physiological responses of invertebrate musculature to endogenous neuropeptide release.
Peptide-receptor interaction analysis: Myomodulin is frequently employed to characterize the pharmacology and signaling properties of neuropeptide receptors. Through ligand-binding assays, receptor activation studies, and downstream signaling analyses, researchers can identify receptor subtypes, map ligand-receptor specificity, and unravel the intracellular pathways triggered by peptide binding. These investigations are essential for defining the molecular determinants of neuropeptide recognition and for developing tools to manipulate peptide signaling in vivo and in vitro.
Peptide structure-function relationship studies: The modular sequence and functional diversity of myomodulin make it an excellent candidate for structure-activity relationship (SAR) research. By synthesizing analogs with targeted amino acid substitutions or modifications, scientists can systematically evaluate how specific residues contribute to receptor affinity, biological potency, and selectivity. Such SAR studies advance the understanding of peptide-receptor interactions, inform the design of novel bioactive peptides, and provide foundational knowledge for the development of neuropeptide-based research tools.
Analytical method development: The unique sequence and chemical properties of myomodulin render it a useful standard or reference compound in the development and validation of analytical techniques for peptide detection and quantification. Mass spectrometry, high-performance liquid chromatography (HPLC), and immunoassay platforms often employ synthetic neuropeptides to optimize sensitivity, specificity, and reproducibility. Utilization of this peptide in method development supports rigorous peptide profiling in complex biological samples, enabling more accurate quantification and identification of endogenous neuropeptides in research settings.
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