N-Boc-N-methyl-(R)-2-allylglycine is a noncanonical amino acid with an allylic side chain and N-methyl substitution, engineered for backbone and side-chain modulation. The Boc group permits orthogonal protection strategies in SPPS. Researchers incorporate the residue to introduce alkene handles for metathesis or click-type transformations. Applications include stapled-peptide design, conformational locking, and late-stage functionalization.
1. TMEM16F and dynamins control expansive plasma membrane reservoirs
2. The spatiotemporal control of signalling and trafficking of the GLP-1R
3. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
4. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
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