(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) is a heavily modified dynorphin fragment engineered for enhanced metabolic stability and conformational control. N-methylation and D-residue incorporation restrict backbone flexibility and protease access. The C-terminal N-ethylamide further alters electronic distribution. Researchers apply this analog to dissect opioid receptor subtype selectivity and short-peptide signaling.
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