N-α-Z-N-δ-trityl-L-glutamine is a protected glutamine derivative in which the α-amino group is carbobenzyloxy (Z/Cbz) protected and the \u03b4-amide side-chain nitrogen is trityl (trityl, Trt) protected, with the glutamine backbone retaining the carboxylic acid functionality. The molecule bears an unprotected γ-carboxamide side chain carbonyl and a free carboxylic acid, while the Z and trityl groups mask the corresponding nitrogens to control chemoselectivity during stepwise peptide assembly and to suppress undesired N-acylation or side reactions. In peptide chemistry and chemical biology workflows, it is used as a protected amino acid building block for introducing a glutamine residue with orthogonal nitrogen protection patterns suitable for preparing glutamine-containing peptides, conjugates, or related amino acid derivatives under controlled deprotection conditions.
CAT No: CP00819
CAS No:132388-60-4
Synonyms/Alias:Z-Gln(Trt)-OH;132388-60-4;Z-L-Gln(Trt)-OH;n-cbz-n'-trityl-l-glutamine;(S)-2-(((Benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoicacid;PubChem15365;CTK0I3329;MolPort-005-933-709;C32H30N2O5;ANW-59233;ZINC15721483;AKOS015960791;AC-12304;AJ-67812;AK-41613;RT-005010;FT-0643175;FT-0653026;ST24035813;X6687;K-4156;J-300130
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